Ugt1a5 Gene Summary [Mouse]
Predicted to enable enzyme binding activity; glucuronosyltransferase activity; and protein dimerization activity. Predicted to be active in endoplasmic reticulum. Orthologous to several human genes including UGT1A5 (UDP glucuronosyltransferase family 1 member A5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ugt1a5 |
| Official Name | UDP glucuronosyltransferase 1 family, polypeptide A5 [Source:MGI Symbol;Acc:MGI:3032634] |
| Ensembl ID | ENSMUSG00000089943 |
| Bio databases IDs | |
| Aliases | UDP glucuronosyltransferase 1 family, polypeptide A5 |
| Synonyms | GNT1, hUG-BR1, HUG-BR2, UDP glucuronosyltransferase 1 family, polypeptide A5, UDP glucuronosyltransferase family 1 member A4, UDP glucuronosyltransferase family 1 member A5, UDPGT, UDPGT 1-4, UDPGT 1-5, UGT1, UGT1-01, UGT1-04, UGT1.1, UGT-1A, UGT1A1, UGT1A4S, Ugt1a5, Ugt1a6, UGT-1D |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ugt1a5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glycosyltransferase family 1 and related proteins with GTB topology
- enzyme inhibitor activity
- glycosyltransferase, MGT family
- enzyme binding
- protein homodimerization
- enzyme
- UDP-glucoronosyl and UDP-glucosyl transferase
- protein heterodimerization
- glucuronosyltransferase
Pathways
Biological processes and signaling networks where the Ugt1a5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- insomnia
- spondylolisthesis
- hepatocellular carcinoma
- cholangiocarcinoma cancer
- cholangiocarcinoma
regulates
- lamotrigine
- androgen
- estrogen
- 25-hydroxy-vitamin D3 3-glucuronide
- clozapine
- 13-hydroxyoctadecadienoic acid
- alcohol
- scopoletin
- quercetin
- troglitazone
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- microsome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ugt1a5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- bilirubin conjugation
- vitamin D3 metabolic process
- cellular glucuronidation
- heme catabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- retinoic acid binding
- protein homodimerization activity
- protein heterodimerization activity
- glucuronosyltransferase activity
- enzyme binding