Rbmx Gene Summary [Mouse]

Predicted to enable several functions, including RNA binding activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in several processes, including RNA metabolic process; membrane protein ectodomain proteolysis; and regulation of RNA metabolic process. Predicted to be located in euchromatin; extracellular exosome; and nucleus. Predicted to be part of catalytic step 2 spliceosome and supraspliceosomal complex. Predicted to be active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including central nervous system; female reproductive system; gut; sensory organ; and thymus. Human ortholog(s) of this gene implicated in X-linked mental retardation Gustavson type and syndromic X-linked intellectual disability Shashi type. Orthologous to human RBMX (RNA binding motif protein X-linked). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Nonsense Mediated Decay
Official Symbol
Rbmx
Official Name
RNA binding motif protein, X chromosome [Source:MGI Symbol;Acc:MGI:1343044]
Ensembl ID
ENSMUSG00000031134
Bio databases IDs NCBI: 19655 Ensembl: ENSMUSG00000031134
Aliases RNA binding motif protein, X chromosome
Synonyms GUST, HNRNPG, HNRPG, MENTAL RETARDATION WITH OPTIC ATROPHY, DEAFNESS, AND SEIZURES, MRXS11, MRXSG, MRXSH, RBMXP1, RBMXRT, RNA binding motif protein, X chromosome, RNA binding motif protein X-linked, RNA binding motif protein, X-linked, RNMX
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rbmx often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • RGG domain
  • RNA recognition motif (RRM) superfamily
  • RNA recognition motif
  • nucleic acid binding
  • mRNA binding
  • chromatin binding
  • protein domain specific binding
  • protein binding
  • sequence-specific DNA binding
  • identical protein binding
  • single-stranded RNA binding
  • RNA binding
  • double-stranded DNA binding
  • RBM1CTR (NUC064) family

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • metastasis
  • neoplasia
  • epithelial cancer
  • epithelial neoplasia
  • cancer
  • androgenic alopecia
  • colon epithelial cancer
  • renal clear cell adenocarcinoma
  • acute myeloid leukemia
  • hepatocellular carcinoma
regulated by
  • SUP-T1 cells
  • tanespimycin
  • CD 437
  • GH1
  • CREB1
  • hydroxyurea
  • Major late
  • Hct 15 cells
  • CEMss cells
  • baicalein
regulates
  • DNA promoter
  • DNA endogenous promoter
  • D-glucose
  • BRCA2
  • RNA polymerase II
  • PKM
  • SMN2
  • transmembrane protein
  • lactic acid
  • TET2
role in cell
  • proliferation
  • expression in
  • growth
  • cisplatin resistance
  • migration
  • alternative splicing by
  • invasion by
  • colony formation by
  • production in
  • migratory capacity

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • glutaminergic synapse
  • catalytic step 2 spliceosome
  • Mitochondria
  • spliceosomes
  • nucleoplasm
  • nucleoli
  • chromatin
  • postsynaptic density
  • exosomes
  • paraspeckle-like structures

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Rbmx gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • membrane protein ectodomain proteolysis
  • positive regulation of nuclear mRNA splicing, via spliceosome
  • regulation of alternative nuclear mRNA splicing, via spliceosome
  • negative regulation of nuclear mRNA splicing, via spliceosome
  • cellular response to interleukin-1
  • osteoblast differentiation
  • protein homooligomerization
  • transcription from RNA polymerase II promoter
  • positive regulation of transcription from RNA polymerase II promoter
  • nuclear mRNA splicing, via spliceosome

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • euchromatin
  • extracellular space
  • extracellular vesicular exosome
  • catalytic step 2 spliceosome
  • membrane
  • spliceosomal complex
  • supraspliceosomal complex
  • macromolecular complex
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • protein domain specific binding
  • identical protein binding
  • RNA binding
  • protein binding
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding
  • mRNA binding
  • chromatin binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.