Fblim1 Gene Summary [Mouse]
Predicted to enable filamin binding activity. Predicted to be involved in cell-cell adhesion and regulation of integrin activation. Predicted to be located in several cellular components, including cell junction; cell periphery; and fibrillar center. Predicted to be active in focal adhesion and stress fiber. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; heart; and hemolymphoid system gland. Orthologous to human FBLIM1 (filamin binding LIM protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fblim1 |
| Official Name | filamin binding LIM protein 1 [Source:MGI Symbol;Acc:MGI:1921452] |
| Ensembl ID | ENSMUSG00000006219 |
| Bio databases IDs | |
| Aliases | filamin binding LIM protein 1 |
| Synonyms | 2410043F08Rik, CAL, DKFZp434G171, FBLI1, FBLP-1, filamin binding LIM protein 1, Gt10, hnRNP L, MIGFILIN, migfilin(s) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fblim1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- filamin binding domain
- cytoskeletal protein binding
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- double-stranded DNA binding
- nucleic acid binding
- protein binding
- sequence-specific DNA binding
- polyproline motif
- proline rich domain
- RNA binding
Pathways
Biological processes and signaling networks where the Fblim1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- androgenic alopecia
- glioma
- glioma formation
- laser induced choroidal neovascularization
- alcoholic pancreatitis
- infection by HIV-1
role in cell
- expression in
- binding in
- activation in
- proliferation
- phosphorylation in
- accumulation in
- differentiation
- migration
- apoptosis
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- fibrillar center
- cell junction
- ribonucleoprotein granule
- Cytoplasm
- cell-matrix contacts
- cell periphery
- focal adhesions
- Nucleus
- actin bundles
- intercellular junctions
- cell-cell contacts
- cytosol
- nucleoplasm
- actin stress fibers
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fblim1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- regulation of integrin activation
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- cytoplasm
- stress fiber
- cytosol
- cell junction
- fibrillar center
- cell periphery
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- filamin binding