Usp49 Gene Summary [Mouse]
Predicted to enable histone binding activity and peptidase activity. Predicted to be involved in mRNA splicing, via spliceosome and negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in cerebral cortex subventricular zone; cerebral cortex ventricular layer; and cortical plate. Orthologous to human USP49 (ubiquitin specific peptidase 49). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Usp49 |
| Official Name | ubiquitin specific peptidase 49 [Source:MGI Symbol;Acc:MGI:2685391] |
| Ensembl ID | ENSMUSG00000090115 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 49 |
| Synonyms | C330046L10Rik, Gm545, MGC20741, RGD1310513, ubiquitin specific peptidase 49 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Usp49 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- cysteine endopeptidase
- Zn-finger in ubiquitin-hydrolases and other protein
- peptidase
- Ubiquitin carboxyl-terminal hydrolase
- ubiquitin-specific protease
- Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger
- enzyme
- protein binding
- Peptidase_C19
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the Usp49 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pancreatic cancer
- insomnia
- psoriasis
- sunburn
regulated by
- atorvastatin
role in cell
- activation in
- proliferation
- survival
- splicing by
- double-stranded DNA break repair in
- phosphorylation in
- deubiquitination in
- breakage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Usp49 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- proteolysis
- nuclear mRNA splicing, via spliceosome
- negative regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- zinc ion binding
- protein binding
- histone binding
- cysteine-type endopeptidase activity