Fkbp4 Gene Summary [Mouse]
Enables several functions, including heat shock protein binding activity; nuclear glucocorticoid receptor binding activity; and purine ribonucleoside triphosphate binding activity. Acts upstream of or within several processes, including androgen receptor signaling pathway; embryo implantation; and steroid hormone receptor complex assembly. Located in nucleus. Is expressed in epithelium of penile urethra; genital tubercle mesenchyme of male; pancreas epithelium; and prepuce of male. Used to study androgen insensitivity syndrome. Orthologous to human FKBP4 (FKBP prolyl isomerase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Fkbp4 |
| Official Name | FK506 binding protein 4 [Source:MGI Symbol;Acc:MGI:95543] |
| Ensembl ID | ENSMUSG00000030357 |
| Bio databases IDs | |
| Aliases | FK506 binding protein 4 |
| Synonyms | FK506 binding protein 4, FKBP18, FKBP51, FKBP-52, FKBP59, FKBP prolyl isomerase 4, FKPB52, HBI, Hsp56, HSP57, Hsp59, p52, p59, PPIase, Tp2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fkbp4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ligand-dependent nuclear receptor interactor
- peptidylprolyl isomerase
- heat shock protein binding
- protein binding activity, bridging
- ATP binding
- calmodulin binding domain
- phosphoprotein binding
- FKBP domain
- enzyme
- protein binding
- BDBT FKBP like N-terminal
- GTP binding
- FKBP-type peptidyl-prolyl cis-trans isomerase
- tau protein binding
- FK506 binding
- Tetratricopeptide repeats
- tetratricopeptide repeat
Pathways
Biological processes and signaling networks where the Fkbp4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma formation
- hyperglycemia
- Huntington disease
- hyperinsulinism
- organismal death
- hairpin sperm flagellum
- pancreatic cancer
- atopic dermatitis
- lung adenocarcinoma
- major depression
role in cell
- expression in
- apoptosis
- motility
- growth
- phosphorylation in
- autophagy in
- formation
- formation in
- migration
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interzone
- axon component
- spindle apparatus
- Cytoplasm
- perinuclear region
- pericentriolar regions
- filamentous network
- centrosome
- centriole
- microtubules
- midbody
- cytosol
- nucleoplasm
- cleavage furrow
- mitotic spindle
- perikaryon
- axons
- detergent-soluble fraction
- cytoskeletal fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fkbp4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chaperone-mediated protein folding
- protein peptidyl-prolyl isomerization
- steroid hormone receptor complex assembly
- protein folding
- embryo implantation
- copper ion transport
- protein complex localization
- negative regulation of neuron projection development
- male sex differentiation
- negative regulation of microtubule polymerization or depolymerization
- androgen receptor signaling pathway
- prostate gland development
- negative regulation of microtubule polymerization
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- axonal growth cone
- cytoplasm
- mitochondrion
- cytosol
- macromolecular complex
- neuronal cell body
- nucleoplasm
- microtubule
Molecular Function
What the gene product does at the molecular level
- heat shock protein binding
- GTP binding
- ATP binding
- peptidyl-prolyl cis-trans isomerase activity
- RNA binding
- protein binding
- FK506 binding
- tau protein binding
- phosphoprotein binding
- copper-dependent protein binding
- protein binding, bridging
- glucocorticoid receptor binding