Hsp90aa1 Gene Summary [Mouse]
Enables identical protein binding activity; nitric-oxide synthase regulator activity; and protein folding chaperone. Involved in several processes, including cellular response to heat; positive regulation of nitric oxide biosynthetic process; and protein folding. Located in several cellular components, including growth cone; neuronal cell body; and perinuclear region of cytoplasm. Part of protein-containing complex. Is expressed in several structures, including 1st branchial arch; alimentary system; eye; gonad; and nervous system. Orthologous to several human genes including HSP90AA1 (heat shock protein 90 alpha family class A member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hsp90aa1 |
| Official Name | heat shock protein 90, alpha (cytosolic), class A member 1 [Source:MGI Symbol;Acc:MGI:96250] |
| Ensembl ID | ENSMUSG00000021270 |
| Bio databases IDs | |
| Aliases | heat shock protein 90, alpha (cytosolic), class A member 1 |
| Synonyms | EL52, Heat shock protein 1, alpha, Heat shock protein 1, α, heat shock protein 90, alpha (cytosolic), class A member 1, heat shock protein 90 alpha family class A member 1, heat shock protein 90, α (cytosolic), class A member 1, heat shock protein 90 α family class A member 1, HEL-S-65p, Hsp103, HSP4, HSP86, HSP86-1, Hsp89, HSP89A, Hsp89-alpha-delta-N, Hsp89-α-δ-N, Hsp90, HSP90A, HSP90-alpha, HSP90N, HSP90-α, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, LAP-2, LOC103692716 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hsp90aa1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CS domain
- Histidine kinase-like ATPase domain
- ATP binding
- protein binding activity, bridging
- enzyme
- pyrimidine nucleotide binding
- identical protein binding
- ATPase
- purine nucleotide binding
- Hsp90 protein
- nitric oxide synthase regulator
- tau protein binding
- ligand-binding domain
- ATPase domain
- PRK05218
- ion channel binding
- ubiquitin protein ligase binding
- nucleotide binding
- dimerization domain
- protein kinase binding
- mRNA binding
- oligomerization domain
- protein phosphatase binding
- enzyme binding
- central domain
- histone deacetylase binding
- protein domain specific binding
- protein binding
- sulfonylurea receptor binding
- acidic domain
- GTP binding
- Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
- binding protein
- adenyl nucleotide binding
- protein homodimerization
- Histidine kinase-like ATPases
- hydrophobic domain
Pathways
Biological processes and signaling networks where the Hsp90aa1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Aldosterone Signaling in Epithelial Cells
- Androgen Signaling
- Aryl Hydrocarbon Receptor Signaling
- eNOS Signaling
- Glucocorticoid Receptor Signaling
- HIF1α Signaling
- Human Embryonic Stem Cell Pluripotency
- Hypoxia Signaling in the Cardiovascular System
- IL-17 Signaling
- Mitotic Roles of Polo-Like Kinase
- Neuregulin Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- NRF2-mediated Oxidative Stress Response
- PPAR Signaling
- PPARα/RXRα Activation
- Prostate Cancer Signaling
- Role of JAK family kinases in IL-6-type Cytokine Signaling
- Role of PKR in Interferon Induction and Antiviral Response
- Telomerase Signaling
- Th17 Activation Pathway
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- gastric cancer
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- advanced biliary tract cancer
- breast cancer
- pain
- neoplasia
- metastatic cervical adenocarcinoma
regulated by
- metformin
- sirolimus
- adenosine triphosphate
- lipopolysaccharide
- oleic acid
- rebemadlin
- secondhand smoke
- cumene hydroperoxide
- TP63
- NEF
role in cell
- growth
- accumulation in
- binding in
- invasion by
- phosphorylation in
- expression in
- migration
- dimerization in
- proliferation
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- membrane fraction
- detergent resistant lipid raft fraction
- axon component
- secretory granule lumen
- ficolin-1-rich granule lumen
- cell surface
- Extracellular Space
- intracellular space
- perinuclear region
- organelle lumens
- Nucleus
- Plasma Membrane
- Mitochondria
- cytosol
- apical membrane
- basolateral membrane
- lysosomal compartment
- inner nuclear membrane
- nucleoplasm
- sperm tail
- myelin sheath
- synaptosomes
- extracellular matrix
- brush border
- perikaryon
- dendrites
- exosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hsp90aa1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of nitric oxide biosynthetic process
- response to estrogen stimulus
- response to salt stress
- positive regulation of protein polymerization
- response to antibiotic
- response to xenobiotic stimulus
- response to unfolded protein
- response to cold
- response to heat
- neuron migration
- cellular response to heat
- positive regulation of cell size
- cardiac muscle cell apoptotic process
- skeletal muscle contraction
- mitochondrial transport
- activation of innate immune response
- positive regulation of interferon-beta production
- regulation of protein ubiquitination
- positive regulation of lamellipodium assembly
- positive regulation of cardiac muscle contraction
- positive regulation of protein import into nucleus
- regulation of protein localization
- response to cocaine
- positive regulation of protein catabolic process
- telomere maintenance via telomerase
- regulation of protein complex assembly
- regulation of apoptotic process
- positive regulation of defense response to virus by host
- protein refolding
- protein folding
- protein unfolding
- protein import into mitochondrial outer membrane
- positive regulation of protein phosphorylation
- chaperone-mediated protein complex assembly
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- myelin sheath
- lysosomal lumen
- neuronal cell body
- extracellular region
- nucleoplasm
- extracellular vesicular exosome
- sperm mitochondrial sheath
- cytosol
- plasma membrane
- cell surface
- nucleus
- dendritic growth cone
- perinuclear region of cytoplasm
- brush border membrane
- melanosome
- axonal growth cone
- cytoplasm
- endocytic vesicle lumen
- membrane
- mitochondrion
- macromolecular complex
- secretory granule lumen
- basolateral plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- GTP binding
- ATP binding
- DNA polymerase binding
- RNA binding
- Rho GDP-dissociation inhibitor binding
- GTPase binding
- dATP binding
- mRNA binding
- identical protein binding
- protein phosphatase binding
- protein homodimerization activity
- histone deacetylase binding
- unfolded protein binding
- MHC class II protein complex binding
- ion channel binding
- UTP binding
- CTP binding
- scaffold protein binding
- TPR domain binding
- protein binding
- ubiquitin protein ligase binding
- tau protein binding
- sulfonylurea receptor binding
- nitric-oxide synthase regulator activity