FBXO28 Gene Summary [Human]
Members of the F-box protein family, such as FBXO28, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | FBXO28 |
| Official Name | F-box protein 28 [Source:HGNC Symbol;Acc:HGNC:29046] |
| Ensembl ID | ENSG00000143756 |
| Bio databases IDs | |
| Aliases | F-box protein 28, centromere protein 30 |
| Synonyms | 4833428J17Rik, 5730505P19Rik, CENP-30, D1Ertd578e, DEE100, F-box protein 28, Fbx28, KIAA0483, LOC100361530, mKIAA0483 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FBXO28 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain superfamily
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- neoplasia
- liver cancer
- major depression
- developmental and epileptic encephalopathy type 100
- organismal death
- hereditary disorder
- pancreatic cancer
- metastasis
- hepatocellular carcinoma
role in cell
- expression in
- migration
- invasion by
- proliferation
- ubiquitination in
- K48 polyubiquitination in
- polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FBXO28 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein polyubiquitination
Cellular Component
Where in the cell the gene product is active
- kinetochore
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding