Ikbkg Gene Summary [Rat]
Enables peroxisome proliferator activated receptor binding activity. Predicted to be involved in several processes, including anoikis; regulation of gene expression; and regulation of signal transduction. Predicted to act upstream of or within B cell homeostasis. Part of IkappaB kinase complex. Used to study irritable bowel syndrome and perinatal necrotizing enterocolitis. Biomarker of acute myocardial infarction. Human ortholog(s) of this gene implicated in Behcet's disease; Bloch-Sulzberger syndrome; X-linked recessive disease (multiple); learning disability; and liver cancer. Orthologous to human IKBKG (inhibitor of nuclear factor kappa B kinase regulatory subunit gamma). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ikbkg |
| Official Name | inhibitor of nuclear factor kappa B kinase regulatory subunit gamma [Source:RGD Symbol;Acc:735223] |
| Ensembl ID | ENSRNOG00000060936 |
| Bio databases IDs | |
| Aliases | inhibitor of nuclear factor kappa B kinase regulatory subunit gamma |
| Synonyms | 1110037D23Rik, AMCBX1, EDAID1, FIP-3, Fip3p, I Kappa B Gamma, IKBK3, IkB γ, IKK3, IKKAP1, IKKG, IKK[g], IKK-gamma, IKK-γ, IMD33, inhibitor of kappaB kinase gamma, inhibitor of kappaB kinase γ, inhibitor of nuclear factor kappa B kinase regulatory subunit gamma, inhibitor of nuclear factor κ B kinase regulatory subunit γ, IP, IP1, IP2, IPD2, I κ B γ, NEMO, NEMO RELATED, SAIDX, ZC2HC9 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ikbkg often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C2H2 type zinc-finger
- NEMO ubiquitin-binding domain
- protein binding activity, bridging
- coiled-coil domain
- leucine zipper domain
- identical protein binding
- NF-kappa-B essential modulator NEMO
- proline rich domain
- leucine-rich repeat
- peroxisome proliferator activated receptor binding
- ubiquitin binding domain
- Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
- IKK binding domain
- ubiquitin protein ligase binding
- leucine rich domain
- IKK alpha/beta binding domain
- UBAN motif
- alpha helix
- ubiquitin binding
- protein domain specific binding
- protein binding
- receptor binding
- phosphorylation site
- kinase
- NEMO-binding domain
- binding protein
- Tank binding domain
- protein homodimerization
- zinc finger domain
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Ikbkg gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- epithelial cancer
- cancer
- liver neoplasia
- liver cancer
- digestive system cancer
- abdominal cancer
- experimental autoimmune encephalomyelitis
- anhidrotic ectodermal dysplasia with immune deficiency
- hereditary disorder
role in cell
- production in
- expression in
- apoptosis
- phosphorylation in
- cell death
- quantity
- activation in
- formation
- formation in
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- soluble fraction
- insoluble fractions
- cytoplasmic fiber
- Cytoplasm
- perinuclear region
- Mitochondria
- immunological synapses
- cytoplasmic particles
- granules
- cytosol
- nucleoplasm
- spindle pole
- membrane rafts
- mitotic spindle
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ikbkg gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of macroautophagy
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- macromolecular complex assembly
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- anoikis
- positive regulation of transcription from RNA polymerase II promoter
- response to DNA damage stimulus
- I-kappaB kinase/NF-kappaB cascade
- response to virus
- positive regulation of NF-kappaB transcription factor activity
- defense response to bacterium
- positive regulation of T cell receptor signaling pathway
- inflammatory response
- immune response
- establishment of vesicle localization
- innate immune response
- apoptotic process
- T cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- ubiquitin ligase complex
- mitotic spindle
- cytoplasm
- IkappaB kinase complex
- spindle pole
- cytosol
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein domain specific binding
- protein binding
- protein homodimerization activity
- ubiquitin protein ligase binding
- K63-linked polyubiquitin binding
- polyubiquitin binding
- signaling adaptor activity
- metal ion binding
- protein heterodimerization activity