Gpr89b Gene Summary [Rat]
Predicted to enable voltage-gated monoatomic anion channel activity. Predicted to be involved in intracellular pH reduction and positive regulation of canonical NF-kappaB signal transduction. Predicted to be located in Golgi-associated vesicle membrane. Predicted to be active in Golgi cisterna membrane. Orthologous to several human genes including GPR89B (G protein-coupled receptor 89B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpr89b |
| Official Name | G protein-coupled receptor 89B [Source:RGD Symbol;Acc:1304837] |
| Ensembl ID | ENSRNOG00000000095 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor 89B |
| Synonyms | 4933412D19Rik, GPHR, GPR89, GPR89B, G protein-coupled receptor 89, G protein-coupled receptor 89A, G protein-coupled receptor 89B, LOC100508578, RGD1304837, SH120, UNQ192 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gpr89b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- voltage-dependent ion-selective channel
- protein binding
- Abscisic acid G-protein coupled receptor
- ion channel
- The Golgi pH Regulator (GPHR) Family N-terminal
Pathways
Biological processes and signaling networks where the Gpr89b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi membrane
- Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gpr89b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- T cell differentiation
- intracellular pH reduction
- protein transport
- positive regulation of I-kappaB kinase/NF-kappaB cascade
Cellular Component
Where in the cell the gene product is active
- Golgi cisterna membrane
- Golgi-associated vesicle membrane
- Golgi membrane
- ion channel complex
Molecular Function
What the gene product does at the molecular level
- voltage-gated anion channel activity