Gpr89 Gene Summary [Mouse]
Predicted to enable voltage-gated monoatomic anion channel activity. Involved in T cell differentiation. Acts upstream of or within skin development. Predicted to be located in Golgi-associated vesicle membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in Golgi cisterna membrane. Is expressed in several structures, including clavicle; ganglia; gut; liver lobe; and ventral grey horn. Orthologous to human GPR89A (G protein-coupled receptor 89A) and GPR89B (G protein-coupled receptor 89B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpr89 |
| Official Name | G protein-coupled receptor 89 [Source:MGI Symbol;Acc:MGI:1914799] |
| Ensembl ID | ENSMUSG00000028096 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor 89 |
| Synonyms | 4933412D19Rik, GPHR, GPR89, GPR89B, G protein-coupled receptor 89, G protein-coupled receptor 89A, G protein-coupled receptor 89B, LOC100508578, RGD1304837, SH120, UNQ192 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gpr89 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- voltage-dependent ion-selective channel
- protein binding
- Abscisic acid G-protein coupled receptor
- ion channel
- The Golgi pH Regulator (GPHR) Family N-terminal
Pathways
Biological processes and signaling networks where the Gpr89 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi membrane
- Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gpr89 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- T cell differentiation
- intracellular pH reduction
- protein transport
- positive regulation of I-kappaB kinase/NF-kappaB cascade
Cellular Component
Where in the cell the gene product is active
- Golgi cisterna membrane
- Golgi-associated vesicle membrane
- Golgi membrane
- ion channel complex
Molecular Function
What the gene product does at the molecular level
- voltage-gated anion channel activity