Txndc15 Gene Summary [Rat]
Predicted to enable 4-alpha-hydroxytetrahydrobiopterin dehydratase activity. Predicted to be involved in cilium assembly and positive regulation of smoothened signaling pathway. Predicted to be located in ciliary membrane. Predicted to be active in cilium. Human ortholog(s) of this gene implicated in Meckel syndrome. Orthologous to human TXNDC15 (thioredoxin domain containing 15). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Txndc15 |
| Official Name | thioredoxin domain containing 15 [Source:RGD Symbol;Acc:1304696] |
| Ensembl ID | ENSRNOG00000000133 |
| Bio databases IDs | |
| Aliases | thioredoxin domain containing 15 |
| Synonyms | 2310047H23Rik, BUG, C5orf14, LOC103690142, MKS14, RGD1304696, thioredoxin domain containing 15, UNQ335 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Txndc15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- enzyme
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cilia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Txndc15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- positive regulation of smoothened signaling pathway
Cellular Component
Where in the cell the gene product is active
- cilium
- cilium membrane
Molecular Function
What the gene product does at the molecular level
- protein binding