Srsf2 Gene Summary [Rat]
Enables protein kinase C binding activity. Involved in response to vitamin E. Located in interchromatin granule; nuclear speck; and perichromatin fibrils. Human ortholog(s) of this gene implicated in acute myeloid leukemia; congestive heart failure; hepatocellular carcinoma; and myelodysplastic syndrome. Orthologous to human SRSF2 (serine and arginine rich splicing factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Srsf2 |
| Official Name | serine and arginine rich splicing factor 2 [Source:RGD Symbol;Acc:1359422] |
| Ensembl ID | ENSRNOG00000000248 |
| Bio databases IDs | |
| Aliases | serine and arginine rich splicing factor 2 |
| Synonyms | D11Wsu175e, Htra2-beta, Htra2-β, Irebf2, MRF-1, PR264, SC-35, serine and arginine-rich splicing factor 2, Sfrs10, SFRS2, SFRS2A, SPLICING FACTOR, ARGININE/SERINE-RICH 2, SRp30a, SRp30b, Tra2-B1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Srsf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- arginine serine dipeptide repeat domain
- RNA recognition motif (RRM) superfamily
- transcription regulator
- RNA recognition motif
- protein kinase C binding
- protein binding
- SR domain
- RNA-binding domain
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- myelodysplastic syndrome with ring sideroblasts
- myelodysplastic syndrome
- primary myelofibrosis
- myelofibrosis
- malignant hematopoietic neoplasm
- hematologic cancer
- myeloproliferative disorder
- myelodysplastic syndrome with multilineage dysplasia
role in cell
- maturation
- cell death
- apoptosis
- quantity
- activation in
- proliferation
- cell viability
- expression in
- growth
- G1 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- perichromatin fibril
- nuclear chromatin
- cytosol
- spliceosomes
- nuclear foci
- interchromatin granules
- nucleoplasm
- nucleoli
- interchromatin granule clusters
- nuclear speckles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Srsf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- negative regulation of transcription, DNA-dependent
- regulation of alternative nuclear mRNA splicing, via spliceosome
- response to vitamin E
- mRNA processing
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- PML body
- perichromatin fibrils
- nuclear speck
- spliceosomal complex
- cytosol
- interchromatin granule
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase C binding
- pre-mRNA binding
- RNA binding
- protein binding
- transcription corepressor activity