Sesn1 Gene Summary [Rat]
Predicted to enable L-leucine binding activity and oxidoreductase activity, acting on peroxide as acceptor. Predicted to be involved in several processes, including cellular response to L-leucine; cellular response to leucine starvation; and negative regulation of TORC1 signaling. Predicted to act upstream of or within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in cytoplasm; fibrillar center; and nucleoplasm. Predicted to be part of GATOR2 complex. Orthologous to human SESN1 (sestrin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sesn1 |
| Official Name | sestrin 1 [Source:RGD Symbol;Acc:1307517] |
| Ensembl ID | ENSRNOG00000000302 |
| Bio databases IDs | |
| Aliases | sestrin 1 |
| Synonyms | 1110002G11Rik, PA26, SEST1, Sestrin 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sesn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- PA26 p53-induced protein (sestrin)
- protein binding
- amino acid binding
Pathways
Biological processes and signaling networks where the Sesn1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- epithelial cancer
- disorder of pregnancy
- prostatic carcinoma
- hypothyroidism
- asthma
regulates
- 20S proteasome
- MTORC1
- reactive oxygen species
- AMPK
role in cell
- growth
- response by
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sesn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of macroautophagy
- reactive oxygen species metabolic process
- cellular response to leucine
- cellular response to amino acid starvation
- cellular response to glucose starvation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- leucine binding
- protein binding
- oxidoreductase activity, acting on peroxide as acceptor