Wdr24 Gene Summary [Rat]
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular response to amino acid starvation; positive regulation of TORC1 signaling; and protein K6-linked ubiquitination. Predicted to act upstream of or within positive regulation of protein kinase activity. Predicted to be located in lysosomal membrane. Predicted to be part of GATOR2 complex. Predicted to be active in cytosol and vacuolar membrane. Orthologous to human WDR24 (WD repeat domain 24). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wdr24 |
| Official Name | WD repeat domain 24 [Source:RGD Symbol;Acc:1304803] |
| Ensembl ID | ENSRNOG00000019713 |
| Bio databases IDs | |
| Aliases | WD repeat domain 24 |
| Synonyms | BC037651, C16ORF21, DKFZp434F054, JFP7, RGD1304803, WD repeat domain 24 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Wdr24 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- RING/Ubox like zinc-binding domain
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- WD domain, G-beta repeat
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- lysosome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Wdr24 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of macroautophagy
- cellular response to nutrient levels
- cellular response to amino acid starvation
- autophagy
- regulation of autophagy
- protein K6-linked ubiquitination
- positive regulation of TOR signaling cascade
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- cytosol
- vacuolar membrane
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding