Ppa1 Gene Summary [Rat]
Predicted to enable G protein activity and amino acid sensor activity. Predicted to be involved in COPII-coated vesicle budding; cellular response to leucine starvation; and negative regulation of TORC1 signaling. Predicted to act upstream of or within negative regulation of cargo loading into COPII-coated vesicle and vesicle-mediated transport. Predicted to be located in Golgi apparatus and sarcoplasmic reticulum. Predicted to be part of COPII vesicle coat. Predicted to be active in endoplasmic reticulum exit site and lysosomal membrane. Orthologous to human SAR1A (secretion associated Ras related GTPase 1A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppa1 |
| Official Name | inorganic pyrophosphatase 1 [Source:RGD Symbol;Acc:1589773] |
| Ensembl ID | ENSRNOG00000000557 |
| Bio databases IDs | |
| Aliases | inorganic pyrophosphatase 1 |
| Synonyms | 2010317E03RIK, HEL-S-66p, inorganic pyrophosphatase 1, IOPPP, IPYR, PP, PP1, Pyp, Pyrophosphatase Inorganic, pyrophosphatase (inorganic) 1, Pyrophosphatase inorganic 1, Pyrophosphate Phosphohydrolase, SID6-8061 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ppa1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Inorganic pyrophosphatase
- pyrophosphatase
- enzyme
- inorganic diphosphatase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- diabetic nephropathy
- lung adenocarcinoma
- lung adenocarcinoma formation
- colorectal cancer
- colorectal adenoma
- colorectal adenoma formation
- idiopathic scoliosis
regulates
- NAD+
- AMP
- ADP-D-ribose
- pyrophosphate
role in cell
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ppa1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphate-containing compound metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- inorganic diphosphatase activity