Setdb1 Gene Summary [Rat]
Predicted to enable DNA binding activity; histone H3K9 trimethyltransferase activity; and promoter-specific chromatin binding activity. Involved in response to ethanol and response to vitamin. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autistic disorder and lung cancer. Orthologous to human SETDB1 (SET domain bifurcated histone lysine methyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Setdb1 |
| Official Name | SET domain bifurcated histone lysine methyltransferase 1 [Source:RGD Symbol;Acc:1308370] |
| Ensembl ID | ENSRNOG00000021143 |
| Bio databases IDs | |
| Aliases | SET domain bifurcated histone lysine methyltransferase 1 |
| Synonyms | ESET, H3-K9-HMTase4, KG1T, KMT1E, LOC100911180, LOC682228, mKIAA0067, SET domain, bifurcated 1, SET domain bifurcated histone lysine methyltransferase 1, TDRD21 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Setdb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Histone methyltransferase Tudor domain
- chromatin binding
- enzyme
- protein binding
- DNA binding
- histone lysine N-methyltransferase activity (H3-K9 specific)
- Domain of unknown function (DUF5604)
- Pre-SET motif
- histone methyltransferase
- Histone methyltransferase Tudor domain 1
- Tudor domain superfamily
- MBD
- N-terminal to some SET domains
Pathways
Biological processes and signaling networks where the Setdb1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- prostate cancer
- prostatic neoplasia
- pelvic cancer
- urogenital cancer
- abdominal cancer
- epithelial cancer
- cancer
- epithelial neoplasia
role in cell
- binding in
- apoptosis
- proliferation
- phosphorylation in
- growth
- cell viability
- migration
- colony formation
- survival
- necroptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- nucleoplasm
- chromatin
- euchromatin compartments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Setdb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heterochromatin organization
- negative regulation of gene expression
- chromatin remodeling
- negative regulation of retroviral genome replication
- positive regulation of methylation-dependent chromatin silencing
- methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- protein binding
- histone methyltransferase activity (H3-K9 specific)
- chromatin binding