Pitpnb Gene Summary [Rat]
Enables phospholipid binding activity and phospholipid transporter activity. Involved in phospholipid transport. Located in Golgi membrane and endoplasmic reticulum membrane. Orthologous to human PITPNB (phosphatidylinositol transfer protein beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pitpnb |
| Official Name | phosphatidylinositol transfer protein, beta [Source:RGD Symbol;Acc:620143] |
| Ensembl ID | ENSRNOG00000000665 |
| Bio databases IDs | |
| Aliases | phosphatidylinositol transfer protein, beta |
| Synonyms | phosphatidylinositol transfer protein beta, phosphatidylinositol transfer protein, beta, phosphatidylinositol transfer protein β, phosphatidylinositol transfer protein, β, PI-TP-beta, PI-TP-β, PtdInsTP, VIB1B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pitpnb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SRPBCC domain
- lipid transporter
- phospholipid binding
- phosphatidylcholine transporter
- binding protein
- phospholipid transporter
- Phosphatidylinositol transfer protein
- phosphatidylinositol transporter
- sphingolipid transporter
- protein binding
- phosphatidylinositol binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- obesity
- breast cancer
- breast carcinoma
- atopic dermatitis
- organismal death
- allergic rhinitis
role in cell
- expression in
- cell death
- dipeptide repeat protein sensitivity
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- lipid droplets
- cytosol
- endoplasmic reticulum membrane
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pitpnb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retrograde vesicle-mediated transport, Golgi to ER
- lipid metabolic process
- phospholipid transport
- nucleus organization
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoplasm
- Golgi apparatus
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- phosphatidylinositol binding
- phosphatidylcholine binding
- phosphatidylinositol transporter activity
- phosphatidylcholine transporter activity