Osbp2 Gene Summary [Rat]
Predicted to enable cholesterol binding activity. Predicted to be involved in lipid transport. Predicted to act upstream of or within spermatid development. Predicted to be located in acrosomal vesicle and apical dendrite. Predicted to be active in cytosol; perinuclear endoplasmic reticulum; and plasma membrane. Orthologous to human OSBP2 (oxysterol binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Osbp2 |
| Official Name | oxysterol binding protein 2 [Source:RGD Symbol;Acc:1310505] |
| Ensembl ID | ENSRNOG00000019645 |
| Bio databases IDs | |
| Aliases | oxysterol binding protein 2 |
| Synonyms | 1700095P05Rik, C630001G20, C630001G20Rik, Gm244, HLM, LOC108352785, ORP-4, OSBPL1, OSBPL4, oxysterol binding protein 2, RGD1309479 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Osbp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cholesterol binding
- PH domain
- protein binding
- Pleckstrin homology-like domain
- Oxysterol-binding protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- colorectal cancer
- schizophrenia
- Takayasu arteritis
- asthenozoospermia
- constipation
- globozoospermia
- oligozoospermia
- teratozoospermia
- post-traumatic stress disorder
role in cell
- phosphorylation in
- activation in
- production in
- apoptosis
- accumulation in
- processing in
- cell death
- molecular cleavage in
- growth
- lack
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- aggregate
- perinuclear filament
- cellular membrane
- Plasma Membrane
- acrosome
- vimentin filaments
- apical processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Osbp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid transport
- spermatid development
Cellular Component
Where in the cell the gene product is active
- perinuclear endoplasmic reticulum
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cholesterol binding