Cdk2ap1 Gene Summary [Rat]
Predicted to enable DNA polymerase binding activity. Predicted to be involved in positive regulation of protein phosphorylation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within face morphogenesis and in utero embryonic development. Predicted to be located in several cellular components, including chromatin; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be part of NuRD complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human CDK2AP1 (cyclin dependent kinase 2 associated protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdk2ap1 |
| Official Name | cyclin-dependent kinase 2 associated protein 1 [Source:RGD Symbol;Acc:1308664] |
| Ensembl ID | ENSRNOG00000001070 |
| Bio databases IDs | |
| Aliases | cyclin-dependent kinase 2 associated protein 1 |
| Synonyms | Apc10, Cdkap1, Cdk associated protein 1, cyclin-dependent kinase 2 associated protein 1, DOC1, DORC1, LOC687549, p12DOC-1, ST19 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cdk2ap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- schizophrenia
- allergy
role in cell
- function
- apoptosis
- quantity
- cell viability
- proliferation
- phosphorylation in
- growth
- binding in
- differentiation
- hyperactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- perinuclear region
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cdk2ap1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein phosphorylation
- DNA-dependent DNA replication
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- NuRD complex
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA polymerase binding
- protein binding