Ift81 Gene Summary [Rat]
Predicted to enable tubulin binding activity. Predicted to be involved in intraciliary transport involved in cilium assembly; regulation of smoothened signaling pathway; and sperm flagellum assembly. Predicted to be located in cytoplasm; microtubule organizing center; and sperm flagellum. Predicted to be part of intraciliary transport particle B. Predicted to be active in ciliary basal body. Human ortholog(s) of this gene implicated in short-rib thoracic dysplasia 19 with or without polydactyly. Orthologous to human IFT81 (intraflagellar transport 81). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ift81 |
| Official Name | intraflagellar transport 81 [Source:RGD Symbol;Acc:727862] |
| Ensembl ID | ENSRNOG00000001294 |
| Bio databases IDs | |
| Aliases | intraflagellar transport 81 |
| Synonyms | CDV-1, CDV-1R, DV1, intraflagellar transport 81, SRTD19 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ift81 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tubulin binding
- Intraflagellar transport 81 calponin homology domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pain
- bipolar I disorder
- hepatocellular carcinoma
- epithelial cancer
- short-rib thoracic dysplasia 19 without polydactyly
- retinal dystrophy
- short-rib thoracic dysplasia 19 with or without polydactyly
- headache
- major depression
- short-rib thoracic dysplasia 19 with polydactyly
role in cell
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- motile cilia
- ciliary tip
- Cytoplasm
- cilia
- basal bodies
- centrosome
- centriole
- sperm midpiece
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ift81 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- intraflagellar transport
- spermatogenesis
- intraflagellar transport involved in cilium morphogenesis
- intraflagellar anterograde transport
- regulation of smoothened signaling pathway
Cellular Component
Where in the cell the gene product is active
- motile cilium
- centrosome
- sperm midpiece
- cilium basal body
- centriole
- cytoplasm
- cilium
- sperm principal piece
- intraflagellar transport particle B
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- protein binding