Cluap1 Gene Summary [Rat]
Predicted to be involved in cilium assembly. Predicted to act upstream of or within axoneme assembly; embryonic morphogenesis; and smoothened signaling pathway. Predicted to be located in several cellular components, including ciliary base; ciliary tip; and cytoskeleton. Predicted to be part of intraciliary transport particle A and intraciliary transport particle B. Predicted to be active in cilium and microtubule organizing center. Orthologous to human CLUAP1 (clusterin associated protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cluap1 |
| Official Name | clusterin associated protein 1 [Source:RGD Symbol;Acc:1359189] |
| Ensembl ID | ENSRNOG00000007117 |
| Bio databases IDs | |
| Aliases | clusterin associated protein 1 |
| Synonyms | 2310030D15Rik, 2610111M03Rik, CFAP22, clusterin associated protein 1, FAP22, IFT38 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cluap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Clusterin-associated protein-1
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- inflammatory bowel disease
- cardiovascular disorder
- situs ambiguus
- Joubert syndrome type 1
- Leber congenital amaurosis type 1
- non-insulin-dependent diabetes mellitus
role in cell
- assembly
- abnormal morphology
- lack
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- intracellular membrane-bounded organelle
- ciliary tip
- cilia
- actin cytoskeleton
- centrosome
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cluap1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- floor plate formation
- neural tube closure
- cilium morphogenesis
- heart looping
- smoothened signaling pathway
- axoneme assembly
- intraflagellar anterograde transport
Cellular Component
Where in the cell the gene product is active
- centrosome
- intracellular membrane-bounded organelle
- cilium
- intraflagellar transport particle B
- intraflagellar transport particle A
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding