Ift52 Gene Summary [Rat]
Predicted to be involved in cilium assembly and intraciliary anterograde transport. Predicted to act upstream of or within several processes, including embryonic morphogenesis; negative regulation of keratinocyte proliferation; and non-motile cilium assembly. Predicted to be located in several cellular components, including ciliary base; ciliary tip; and microtubule organizing center. Predicted to be part of intraciliary transport particle B. Predicted to be active in centriole and cilium. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy. Orthologous to human IFT52 (intraflagellar transport 52). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ift52 |
| Official Name | intraflagellar transport 52 [Source:RGD Symbol;Acc:1311004] |
| Ensembl ID | ENSRNOG00000007692 |
| Bio databases IDs | |
| Aliases | intraflagellar transport 52 |
| Synonyms | AU015812, C20orf9, CGI-53, intraflagellar transport 52, LOC684302, NGD2, NGD5, RGD1311004 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ift52 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- short-rib thoracic dysplasia type 16 with polydactyly
- non-insulin-dependent diabetes mellitus
- short rib-polydactyly syndrome
- short-rib thoracic dysplasia type 16 with or without polydactyly
- short-rib thoracic dysplasia 16 without polydactyly
role in cell
- proliferation
- assembly
- clustering in
- clustering
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- motile cilia
- ciliary tip
- non-motile cilium
- cilia
- basal bodies
- centrosome
- centriole
- connecting cilia
- neurites
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ift52 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of keratinocyte proliferation
- neural tube formation
- keratinocyte proliferation
- cilium morphogenesis
- intraflagellar transport
- smoothened signaling pathway
- heart looping
- intraflagellar anterograde transport
- dorsal/ventral pattern formation
- embryonic digit morphogenesis
- regulation of protein processing
Cellular Component
Where in the cell the gene product is active
- dendrite terminus
- photoreceptor connecting cilium
- motile cilium
- centrosome
- cilium basal body
- centriole
- cilium
- intraflagellar transport particle B
Molecular Function
What the gene product does at the molecular level
- protein binding