Mettl7a Gene Summary [Rat]
Predicted to enable mRNA m(6)A methyltransferase activity and thiol S-methyltransferase activity. Predicted to be involved in lncRNA processing; odontogenesis; and osteoblast differentiation. Predicted to be located in endoplasmic reticulum and lipid droplet. Orthologous to human TMT1A (thiol methyltransferase 1A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mettl7a |
| Official Name | methyltransferase like 7A [Source:RGD Symbol;Acc:1308407] |
| Ensembl ID | ENSRNOG00000001376 |
| Bio databases IDs | |
| Aliases | methyltransferase like 7A |
| Synonyms | AAM-B, DKFZp586A0522, LOC100362962, METTL7A, RGD1308407, thiol methyltransferase 1A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mettl7a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA (N6-adenosine)-methyltransferase
- precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit
- RNA methyltransferase
- thiol S-methyltransferase
- enzyme
- protein binding
- AdoMet_MTases
- methyltransferase domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- COVID-19
- organismal death
- lung adenocarcinoma
- lung adenocarcinoma formation
- lung squamous cell carcinoma
- squamous cell lung cancer
- urothelial bladder carcinoma
- transitional cell bladder cancer
- prostate cancer
role in cell
- expression in
- proliferation
- migration
- differentiation
- colony formation
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- organelle lumens
- Endoplasmic Reticulum
- lipid droplets
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mettl7a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- osteoblast differentiation
- odontogenesis
- methylation
Cellular Component
Where in the cell the gene product is active
- lipid particle
- membrane
- cytosol
- endoplasmic reticulum
- extracellular region
Molecular Function
What the gene product does at the molecular level
- RNA methyltransferase activity
- protein binding
- mRNA (N6-adenosine)-methyltransferase activity
- thiol S-methyltransferase activity
- methyltransferase activity