Tmem120a Gene Summary [Rat]
Predicted to enable coenzyme A binding activity and monoatomic ion channel activity. Predicted to be involved in several processes, including antiviral innate immune response; detection of mechanical stimulus involved in sensory perception of pain; and protein complex oligomerization. Predicted to be located in endoplasmic reticulum; nuclear inner membrane; and plasma membrane. Predicted to be active in membrane. Orthologous to human TMEM120A (transmembrane protein 120A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmem120a |
| Official Name | transmembrane protein 120A [Source:RGD Symbol;Acc:1311474] |
| Ensembl ID | ENSRNOG00000001441 |
| Bio databases IDs | |
| Aliases | transmembrane protein 120A |
| Synonyms | 2010310D06RIK, NET29, RGD1311474, TACAN, TMPIT, transmembrane protein 120A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tmem120a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- protein binding
- TMPIT-like protein
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cutaneous melanoma
- cutaneous melanoma cancer
- sarcoidosis
- opioid-related disorder
- infection by Zika virus
regulated by
- Ebna3c
- PPARD
- gentamicin
role in cell
- expression in
- phosphorylation in
- differentiation
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Endoplasmic Reticulum
- inner nuclear membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tmem120a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transmembrane transport
- protein homooligomerization
- detection of mechanical stimulus involved in sensory perception of pain
- protein heterooligomerization
- fat cell differentiation
Cellular Component
Where in the cell the gene product is active
- nuclear inner membrane
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ion channel activity
- protein binding