Atp5f1a Gene Summary [Rat]
Enables ADP binding activity; ATP binding activity; and protease binding activity. Contributes to ATP hydrolysis activity. Involved in several processes, including cellular response to dexamethasone stimulus; cellular response to nitric oxide; and response to muscle activity. Located in cell surface; membrane raft; and mitochondrial inner membrane. Part of proton-transporting ATP synthase complex. Used to study metabolic dysfunction-associated steatotic liver disease and pulmonary hypertension. Biomarker of Alzheimer's disease and hypertension. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 22; mitochondrial complex V (ATP synthase) deficiency nuclear type 4A; and mitochondrial complex V (ATP synthase) deficiency nuclear type 4B. Orthologous to human ATP5F1A (ATP synthase F1 subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp5f1a |
| Official Name | ATP synthase F1 subunit alpha [Source:RGD Symbol;Acc:619993] |
| Ensembl ID | ENSRNOG00000017032 |
| Bio databases IDs | |
| Aliases | ATP synthase F1 subunit alpha |
| Synonyms | AL022851, alpha subunit of the F1F0 ATP SYNTHASE (COMPLEX V), ATP5A, ATP5A1, ATP5AL2, ATPA, ATPD, ATPM, ATP synthase alpha, Atp synthase alpha chain, ATP SYNTHASE alpha subunit, Atp synthase (f0f1), subunit alpha, Atp synthase (f0f1), subunit α, ATP Synthase F1 alpha, ATP synthase F1 subunit alpha, ATP synthase F1 subunit α, ATP Synthase F1 α, ATP synthase mitochondrial f1complex, ATP synthase α, Atp synthase α chain, ATP SYNTHASE α subunit, Complex V subunit I, COXPD22, D18Ertd206e, F1 atpase, F1 ATPase alpha, F1 ATPase α, hATP1, HEL-S-123m, MC5DN4, MC5DN4A, MC5DN4B, Mitochondrial ATPS, MOM2, OMR, ORM, Q3u452, α subunit of the F1F0 ATP SYNTHASE (COMPLEX V) |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Atp5f1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MHC class I protein binding
- adenosine-tetraphosphatase
- protease binding
- ADP binding
- ATP-synt_F1_V1_A1_AB_FliI_N
- ATP synthase alpha/beta family, nucleotide-binding domain
- ATP binding
- protein binding
- hydrogen-transporting ATP synthase activity, rotational mechanism
- ATPase
- ATP synthase alpha/beta family, beta-barrel domain
- proton translocating ATP synthase, F1 alpha subunit
- ATP-synt_F1_V1_A1_AB_FliI_C
- ATP synthase alpha/beta chain, C terminal domain
- alternate F1F0 ATPase, F1 subunit alpha
- P-loop containing Nucleoside Triphosphate Hydrolases
- transporter
Pathways
Biological processes and signaling networks where the Atp5f1a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- colorectal cancer
- hereditary disorder
- idiopathic scoliosis
- Alzheimer disease
- mitochondrial complex V deficiency nuclear type 4A
- androgenic alopecia
- combined oxidative phosphorylation deficiency 22
- chronic sinusitis
- mitochondrial complex V deficiency nuclear type 4B
role in cell
- migration
- expression in
- proliferation
- growth
- morphology
- cell death
- Gap 0-Gap 1 phase
- survival
- formation in
- mitochondrial respiration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cristae-like membrane
- cell surface
- cellular membrane
- Plasma Membrane
- Mitochondria
- synaptic membrane
- Golgi membrane
- mitochondrial membrane
- mitochondrial matrix
- mitochondrial inner membrane
- inner nuclear membrane
- nuclear scaffolds
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Atp5f1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to ethanol
- response to muscle activity
- lipid metabolic process
- cellular response to nitric oxide
- negative regulation of endothelial cell proliferation
- ATP biosynthetic process
- cellular response to dexamethasone stimulus
- ATP synthesis coupled proton transport
- positive regulation of blood vessel endothelial cell migration
- mitochondrial ATP synthesis coupled proton transport
Cellular Component
Where in the cell the gene product is active
- proton-transporting ATP synthase complex
- mitochondrial inner membrane
- plasma membrane
- mitochondrial proton-transporting ATP synthase, catalytic core
- cell surface
- mitochondrial proton-transporting ATP synthase complex
- proton-transporting ATP synthase complex, catalytic core F(1)
- extracellular vesicular exosome
- mitochondrial matrix
- mitochondrion
- membrane raft
- membrane
- signalosome
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- RNA binding
- protein binding
- angiostatin binding
- protease binding
- MHC class I protein binding
- ADP binding
- hydrogen ion transporting ATP synthase activity, rotational mechanism