Hoxd12 Gene Summary [Rat]
Predicted to enable sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within embryonic digit morphogenesis; pattern specification process; and skeletal system development. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Human ortholog(s) of this gene implicated in clubfoot. Orthologous to human HOXD12 (homeobox D12). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hoxd12 |
| Official Name | homeo box D12 [Source:RGD Symbol;Acc:1309797] |
| Ensembl ID | ENSRNOG00000001587 |
| Bio databases IDs | |
| Aliases | homeo box D12 |
| Synonyms | homeo box D12, Hox-4.7, HOX4H, Hox-5.6 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hoxd12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- protein binding
- sequence-specific DNA binding
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- agenesis
- soft tissue sarcoma cancer
- synovial sarcoma
- brachyphalangia
role in cell
- differentiation
- proliferation
- expression in
- G1 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hoxd12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- skeletal system development
- pattern specification process
- regulation of transcription from RNA polymerase II promoter
- embryonic digit morphogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity