Nefm Gene Summary [Rat]
Enables signaling receptor binding activity and toxic substance binding activity. Involved in several processes, including cellular response to estradiol stimulus; intermediate filament cytoskeleton organization; and nervous system development. Located in axon; neurofilament; and perikaryon. Used to study amyotrophic lateral sclerosis and congenital hypothyroidism. Biomarker of hypothyroidism; sciatic neuropathy; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Alzheimer's disease and human immunodeficiency virus infectious disease. Orthologous to human NEFM (neurofilament medium chain). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nefm |
| Official Name | neurofilament medium [Source:RGD Symbol;Acc:3160] |
| Ensembl ID | ENSRNOG00000013916 |
| Bio databases IDs | |
| Aliases | neurofilament medium |
| Synonyms | NEF3, neurofilament medium chain, neurofilament, medium polypeptide, Neurofilament triplet m, Nf145, NF-150KD, NF160, NF165, NF-M |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nefm often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Intermediate filament head (DNA binding) region
- microtubule binding
- binding protein
- structural constituent of cytoskeleton
- Autophagy protein ATG17-like domain
- Lys-Ser-Pro repeat
- tail domain
- protein binding
- receptor binding
- Intermediate filament protein
- toxin binding
Pathways
Biological processes and signaling networks where the Nefm gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pancreatic cancer
- schizophrenia
- ductal breast carcinoma
- ductal breast cancer
- hypothyroidism
- paralysis
- early onset osteoarthritis
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- amyotrophic lateral sclerosis
- motor neuron disease
role in cell
- quantity
- growth
- survival
- accumulation
- degeneration
- development
- number
- organization
- clustering
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- myelin enriched fraction
- soluble fraction
- postsynaptic density (PSD) fractions
- intermediate filament cytoskeleton
- cytoskeleton
- Cytoplasm
- intracellular space
- cellular membrane
- intermediate filaments
- neurofilaments
- neuromuscular junctions
- neurites
- fibrils
- membrane processes
- perikaryon
- axons
- dendrites
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nefm gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neurofilament bundle assembly
Cellular Component
Where in the cell the gene product is active
- intermediate filament cytoskeleton
- cytoplasm
- intermediate filament
- neurofilament
- axon
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural constituent of cytoskeleton
- microtubule binding