Cdk1 Gene Summary [Rat]
Enables cyclin-dependent protein serine/threonine kinase activity and histone kinase activity. Involved in several processes, including Golgi disassembly; positive regulation of cardiac muscle cell proliferation; and positive regulation of protein import into nucleus. Acts upstream of or within negative regulation of gene expression. Located in cytosol. Human ortholog(s) of this gene implicated in breast cancer; cervical cancer; and urinary bladder cancer. Orthologous to human CDK1 (cyclin dependent kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdk1 |
| Official Name | cyclin-dependent kinase 1 [Source:RGD Symbol;Acc:2319] |
| Ensembl ID | ENSRNOG00000000632 |
| Bio databases IDs | |
| Aliases | cyclin-dependent kinase 1 |
| Synonyms | CDC2, CDC28A, Cdc2a, CDC2 kinase, cyclin-dependent kinase 1, GROWTH-ASSOCIATED HISTONE H1 KINASE, p34, P34CDC2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cdk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cyclin-dependent protein kinase
- protein serine/threonine kinase
- [RNA-polymerase]-subunit kinase
- Hsp70 protein binding
- protein kinase
- ATP-binding domain
- chromatin binding
- coiled-coil domain
- enzyme
- protein binding
- Protein kinase domain
- phosphorylation site
- cyclin binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- alcohol group acceptor phosphotransferase
Pathways
Biological processes and signaling networks where the Cdk1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Apoptosis Signaling
- ATM Signaling
- Cell Cycle Control of Chromosomal Replication
- Cyclins and Cell Cycle Regulation
- DNA damage-induced 14-3-3σ Signaling
- DNA Methylation and Transcriptional Repression Signaling
- Estrogen-mediated S-phase Entry
- GADD45 Signaling
- Hereditary Breast Cancer Signaling
- Mitotic Roles of Polo-Like Kinase
- Molecular Mechanisms of Cancer
- Regulation of Cellular Mechanics by Calpain Protease
- Role of CHK Proteins in Cell Cycle Checkpoint Control
- Sonic Hedgehog Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lymphomagenesis
- lymphatic neoplasia
- neoplasia
- Alzheimer disease
- tumorigenesis
- rectal adenocarcinoma
- colorectal carcinomagenesis
- rectum cancer
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
role in cell
- cell death
- proliferation
- differentiation
- expression in
- apoptosis
- growth
- development
- accumulation
- survival
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- detergent resistant lipid raft fraction
- Cytoplasm
- ribosome
- centrosome
- Endoplasmic Reticulum
- Mitochondria
- midbody
- cytosol
- endoplasmic reticulum membrane
- mitochondrial matrix
- nucleoplasm
- nuclear rim
- spindle fibers
- germinal vesicles
- mitotic spindle
- kinetochores
- perikaryon
- lamellipodia
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cdk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cardiac muscle cell proliferation
- DNA repair
- mitotic cell cycle G2/M transition DNA damage checkpoint
- centrosome cycle
- response to axon injury
- response to toxin
- apoptotic process
- protein localization to kinetochore
- positive regulation of G2/M transition of mitotic cell cycle
- positive regulation of protein localization to nucleus
- positive regulation of protein import into nucleus
- macromolecular complex assembly
- response to amine stimulus
- chromosome condensation
- pronuclear fusion
- microtubule cytoskeleton organization
- response to DNA damage stimulus
- epithelial cell differentiation
- negative regulation of gene expression
- positive regulation of gene expression
- ventricular cardiac muscle cell development
- organ regeneration
- response to activity
- peptidyl-serine phosphorylation
- cellular response to organic cyclic compound
- peptidyl-threonine phosphorylation
- viral entry into host cell
- mitotic nuclear envelope disassembly
- DNA replication
- positive regulation of DNA replication
- response to xenobiotic stimulus
- regulation of circadian rhythm
- protein phosphorylation
- cell division
- fibroblast proliferation
- response to ethanol
- chromatin remodeling
- G2/M transition of mitotic cell cycle
- G1/S transition of mitotic cell cycle
- cellular response to hydrogen peroxide
- cell migration
- regulation of Schwann cell differentiation
- Golgi disassembly
- response to copper ion
- regulation of embryonic development
- response to cadmium ion
- regulation of transcription from RNA polymerase II promoter
- ERK1 and ERK2 cascade
- rhythmic process
- negative regulation of apoptotic process
Cellular Component
Where in the cell the gene product is active
- cyclin-dependent protein kinase holoenzyme complex
- nucleoplasm
- endoplasmic reticulum membrane
- cyclin A2-CDK1 complex
- chromosome, telomeric region
- nucleus
- cyclin A1-CDK1 complex
- spindle microtubule
- centrosome
- extracellular vesicular exosome
- mitotic spindle
- cytoplasm
- cyclin B1-CDK1 complex
- mitochondrial matrix
- membrane
- mitochondrion
- cytosol
- midbody
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II carboxy-terminal domain kinase activity
- histone kinase activity
- protein kinase activity
- chromatin binding
- cyclin-dependent protein kinase activity
- protein serine/threonine kinase activity
- ATP binding
- protein binding
- viral receptor activity
- cyclin binding
- kinase activity
- Hsp70 protein binding