Pcp4 Gene Summary [Rat]
The protein encoded by this gene regulates H1Ëš and H3.3 histone synthesis by binding to H1Ëš and H3.3 histone mRNAs. The encoded protein can bind calmodulin as well, providung a possible link between calcium-dependent signals and histone metabolism. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
Details
| Type | Protein Coding |
| Official Symbol | Pcp4 |
| Official Name | Purkinje cell protein 4 [Source:RGD Symbol;Acc:3271] |
| Ensembl ID | ENSRNOG00000001628 |
| Bio databases IDs | |
| Aliases | Purkinje cell protein 4 |
| Synonyms | LOC102551106, P16Rimb19, PEP-19, PEPZ19, Purkinje cell protein 4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pcp4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calmodulin binding
- calcium ion binding
- protein binding
- acidic domain
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nodular goiter
- schizophrenia
- uterine leiomyoma
- leiomyomatosis
- Alzheimer disease
- idiopathic pulmonary fibrosis
- melanoma
- melanoma cancer
- psoriasis
- Huntington disease
regulates
- Ca2+
- dopamine
- CaMKII
- neurotransmitter
role in cell
- apoptosis
- differentiation
- development
- long-term potentiation in
- oscillation in
- plasticity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- neurofilaments
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pcp4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of neuron differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- protein binding
- calcium ion binding