Apod Gene Summary [Rat]
Predicted to enable cholesterol binding activity. Involved in peripheral nervous system axon regeneration; response to xenobiotic stimulus; and tissue regeneration. Located in cytosolic ribosome; dendrite; and neuronal cell body. Biomarker of status epilepticus and vasculogenic impotence. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human APOD (apolipoprotein D). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Apod |
| Official Name | apolipoprotein D [Source:RGD Symbol;Acc:2137] |
| Ensembl ID | ENSRNOG00000048273 |
| Bio databases IDs | |
| Aliases | apolipoprotein D |
| Synonyms | AOPDGN, apolipoprotein D, LOC100047583 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Apod often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cholesterol binding
- lipocalin/cytosolic fatty acid-binding protein family
- protein binding
- Lipocalin / cytosolic fatty-acid binding protein family
- transporter
Pathways
Biological processes and signaling networks where the Apod gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Airway Pathology in Chronic Obstructive Pulmonary Disease
- Atherosclerosis Signaling
- Clathrin-mediated Endocytosis Signaling
- FXR/RXR Activation
- IL-12 Signaling and Production in Macrophages
- LXR/RXR Activation
- Maturity Onset Diabetes of Young (MODY) Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- hypertrophic scarring
- psoriasis
- aldosterone producing adrenocortical adenoma
- adenoma formation
- chromophobe renal cell carcinoma
- chromophobe renal cancer
- Huntington disease
- lung squamous cell carcinoma
- squamous cell lung cancer
role in cell
- proliferation
- cell viability
- number
- assembly
- regulation
- cellular infiltration by
- migration by
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- intracellular space
- perinuclear region
- cellular membrane
- ribosome
- Plasma Membrane
- vesicles
- Endoplasmic Reticulum
- granules
- cytosol
- nuclear envelope
- perikaryon
- dendrites
- phagosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Apod gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peripheral nervous system axon regeneration
- negative regulation of protein import into nucleus
- negative regulation of smooth muscle cell-matrix adhesion
- negative regulation of cytokine production involved in inflammatory response
- response to axon injury
- brain development
- glucose metabolic process
- tissue regeneration
- response to reactive oxygen species
- negative regulation of lipoprotein lipid oxidation
- negative regulation of focal adhesion assembly
- lipid transport
- negative regulation of T cell migration
- angiogenesis
- negative regulation of smooth muscle cell proliferation
- lipid metabolic process
- negative regulation of monocyte chemotactic protein-1 production
- negative regulation of platelet-derived growth factor receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- dendrite
- extracellular space
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- cytosolic ribosome
- cytoplasm
- endoplasmic reticulum
- neuronal cell body
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- cholesterol binding
- lipid transporter activity