Riox2 Gene Summary [Rat]
Predicted to enable several functions, including histone H3 demethylase activity; peptidyl-histidine dioxygenase activity; and transcription corepressor activity. Predicted to be involved in chromatin remodeling; negative regulation of DNA-templated transcription; and ribosome biogenesis. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleolus. Orthologous to human RIOX2 (ribosomal oxygenase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Riox2 |
| Official Name | ribosomal oxygenase 2 [Source:RGD Symbol;Acc:708521] |
| Ensembl ID | ENSRNOG00000001680 |
| Bio databases IDs | |
| Aliases | ribosomal oxygenase 2 |
| Synonyms | 1810047J07Rik, 2410057H13Rik, 3830408E23Rik, JMJD10, MDIG, MINA, MINA53, NO52, ribosomal oxygenase 2, ROX |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Riox2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ROXA-like winged helix
- transcription regulator
- 2-oxoglutarate:oxygen oxidoreductase
- transcription co-repressor
- enzyme
- protein binding
- JmjC domain
- histone demethylase activity
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- lung squamous cell carcinoma
- squamous cell lung cancer
- urinary tract obstruction
regulates
- IL4
- Immunoglobulin
role in cell
- proliferation
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Riox2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- negative regulation of transcription, DNA-dependent
- ribosome biogenesis
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- metal ion binding
- transcription corepressor activity
- histone demethylase activity
- histone demethylase activity (H3-K4 specific)
- histone demethylase activity (H3-K36 specific)
- peptidyl-histidine dioxygenase activity