Ehhadh Gene Summary [Rat]
Enables several functions, including 3-hydroxyacyl-CoA dehydrogenase activity; delta(3)-delta(2)-enoyl-CoA isomerase activity; and enoyl-CoA hydratase activity. Involved in fatty acid beta-oxidation. Located in cytosol and peroxisome. Human ortholog(s) of this gene implicated in Fanconi renotubular syndrome 3. Orthologous to human EHHADH (enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ehhadh |
| Official Name | enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase [Source:RGD Symbol;Acc:621441] |
| Ensembl ID | ENSRNOG00000001770 |
| Bio databases IDs | |
| Aliases | enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase |
| Synonyms | 1300002P22Rik, BIEN, Bif, ECHD, enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase, enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase, FRTS3, Had, HD, LBFP, L-bifunctional, LBP, Lmbop, L-PBE, L-Specific Multifunctional Beta Oxidation, L-Specific Multifunctional β Oxidation, MEF, Mfe, MFE1, MFP, MFP-1, Pbe, PBFE, pe-CoA, perMFE-1, Peroxisomal 3,2-enoyl-CoA isomerase, Peroxisomal Bifunctional Enzyme, PPA |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ehhadh often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- carbon-carbon double bond transposing intramolecular oxidoreductase
- dodecenoyl-CoA D-isomerase
- 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
- 3-hydroxyacyl-CoA dehydrogenase
- crotonase-like
- fatty acid oxidation complex, alpha subunit, mitochondrial
- enzyme binding
- enzyme
- protein binding
- AdoMet_MTases
- long-chain-3-hydroxyacyl-CoA dehydrogenase
- enoyl-CoA hydratase
- 3-hydroxyacyl-CoA dehydratase
- 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
Pathways
Biological processes and signaling networks where the Ehhadh gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- growth failure
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- Fanconi renotubular syndrome type 3
- hypotonia
- insomnia
- renal clear cell adenocarcinoma
- renal clear cell cancer
- colorectal cancer
role in cell
- beta-oxidation in
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- peroxisomal matrix
- Mitochondria
- cytosol
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ehhadh gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fatty acid beta-oxidation
- fatty acid beta-oxidation using acyl-CoA oxidase
Cellular Component
Where in the cell the gene product is active
- peroxisome
- cytosol
- peroxisomal matrix
Molecular Function
What the gene product does at the molecular level
- 3-hydroxyacyl-CoA dehydratase activity
- protein binding
- 3-hydroxyacyl-CoA dehydrogenase activity
- long-chain-3-hydroxyacyl-CoA dehydrogenase activity
- dodecenoyl-CoA delta-isomerase activity
- enoyl-CoA hydratase activity
- intramolecular oxidoreductase activity, transposing C=C bonds
- NAD+ binding
- enzyme binding