Pstpip1 Gene Summary [Rat]
Predicted to enable actin binding activity; identical protein binding activity; and protein phosphatase binding activity. Predicted to be located in actin cytoskeleton; cleavage furrow; and cytosol. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in PAPA syndrome. Orthologous to human PSTPIP1 (proline-serine-threonine phosphatase interacting protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pstpip1 |
| Official Name | proline-serine-threonine phosphatase-interacting protein 1 [Source:RGD Symbol;Acc:1307557] |
| Ensembl ID | ENSRNOG00000016413 |
| Bio databases IDs | |
| Aliases | proline-serine-threonine phosphatase-interacting protein 1 |
| Synonyms | AICZC, CD2BP1, CD2BP1L, CD2BP1S, def-2, H-PIP, PAPA, PAPAS, proline-serine-threonine phosphatase-interacting protein 1, PSTPIP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pstpip1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin binding
- protein phosphatase binding
- Fes/CIP4, and EFC/F-BAR homology domain
- coiled-coil domain
- protein binding
- Bin/Amphiphysin/Rvs domain
- identical protein binding
- phosphorylation site
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- migraines
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
- familial recurrent arthritis
- rheumatoid arthritis
- gastroesophageal reflux
- Behcet disease
- idiopathic meningoencephalitis
- cholelithiasis
- coronary artery disease
role in cell
- activation in
- formation
- function
- abnormal morphology
- endocytosis in
- induction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- actin cytoskeleton
- Plasma Membrane
- contractile rings
- actin bundles
- cytosol
- cortical actin filaments
- actin stress fibers
- cleavage furrow
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pstpip1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- signal transduction
- innate immune response
- actin filament polymerization
- cell adhesion
- endocytosis
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- uropod
- cytoplasm
- cleavage furrow
- membrane
- cytosol
- actin filament
- plasma membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- identical protein binding
- protein binding