Fasn Gene Summary [Rat]
Enables [acyl-carrier-protein] S-malonyltransferase activity; fatty acid synthase activity; and identical protein binding activity. Involved in acetyl-CoA metabolic process; fatty acid biosynthetic process; and response to nutrient. Located in cytoplasm. Biomarker of metabolic dysfunction-associated steatotic liver disease. Orthologous to human FASN (fatty acid synthase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fasn |
| Official Name | fatty acid synthase [Source:RGD Symbol;Acc:620665] |
| Ensembl ID | ENSRNOG00000045636 |
| Bio databases IDs | |
| Aliases | fatty acid synthase |
| Synonyms | A630082H08Rik, FAS, FASH, fatty acid synthase, Long chain fatty acyl-coa synthetase, NADP Dependent Oxidoreductase, nFAS, OA-519, SDR27X1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fasn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- malonyl CoA-acyl carrier protein transacylase
- Beta-ketoacyl synthase domain
- MDR
- Zinc-binding dehydrogenase
- Ketoacyl-synthetase C-terminal extension
- [acyl-carrier-protein] S-acetyltransferase
- enzyme
- Beta-ketoacyl synthase, C-terminal domain
- AdoMet_MTases
- Enoyl reductase domain
- identical protein binding
- methyltransferase domain
- polyketide synthase keto reductase domain
- 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase
- putative NAD(P)H quinone oxidoreductase, PIG3 family
- enoyl-[acyl-carrier-protein] reductase (NADPH2, A-specific)
- hot_dog
- 3-oxoacyl-[acyl-carrier-protein] reductase
- [acyl-carrier-protein] S-malonyltransferase
- 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase
- Phosphopantetheine attachment site
- Beta-ketoacyl reductase domain
- alpha/beta hydrolases
- KR domain
- central domain
- Acyl transferase domain
- protein binding
- Enoylreductase
- dehydrase domain
- cond_enzymes
- acyl carrier protein domain
- Malonyl-acetyl transferase domain
- binding protein
- Beta-ketoacyl synthase
- Thioesterase domain
- 3-oxoacyl-[acyl-carrier-protein] synthase
- crotonoyl-[acyl-carrier-protein] hydratase
- oleoyl-[acyl-carrier-protein] hydrolase
- fatty-acid synthase
Pathways
Biological processes and signaling networks where the Fasn gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- diabetes mellitus
- pancreatic cancer
- prostate cancer
- nonalcoholic steatohepatitis
- obesity
- liver cancer
- recurrent glioblastoma
- glioblastoma
role in cell
- phosphorylation in
- activation in
- apoptosis
- cell viability
- production in
- expression in
- proliferation
- differentiation
- cell death
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- extracellular vesicles
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- growth cone
- perikaryon
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fasn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mammary gland development
- inflammatory response
- cellular response to interleukin-4
- osteoblast differentiation
- fatty acid biosynthetic process
- monocyte differentiation
- neutrophil differentiation
- glandular epithelial cell development
- fatty acid metabolic process
- ether lipid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- melanosome
- membrane
- cytosol
- Golgi apparatus
- glycogen granule
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity
- [acyl-carrier-protein] S-acetyltransferase activity
- fatty acid synthase activity
- 3-oxoacyl-[acyl-carrier-protein] synthase activity
- 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
- crotonoyl-[acyl-carrier-protein] hydratase activity
- [acyl-carrier-protein] S-malonyltransferase activity
- 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
- (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity
- 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
- protein binding
- RNA binding
- cadherin binding
- acyl-[acyl-carrier-protein] hydrolase activity
- phosphopantetheine binding