Abcd3 Gene Summary [Rat]
Enables ATP binding activity and identical protein binding activity. Involved in response to xenobiotic stimulus. Located in mitochondrion and peroxisomal membrane. Human ortholog(s) of this gene implicated in Zellweger syndrome and congenital bile acid synthesis defect 5. Orthologous to human ABCD3 (ATP binding cassette subfamily D member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Abcd3 |
| Official Name | ATP binding cassette subfamily D member 3 [Source:RGD Symbol;Acc:2007] |
| Ensembl ID | ENSRNOG00000011929 |
| Bio databases IDs | |
| Aliases | ATP binding cassette subfamily D member 3 |
| Synonyms | ABC43, ATP binding cassette subfamily D member 3, ATP-binding cassette, sub-family D member 3, CBAS5, PMP68, PMP70, PXMP1, ZWS2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Abcd3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase activity, coupled to transmembrane movement of substances
- Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein
- lipid A export permease/ATP-binding protein MsbA
- walker type A motif
- ATP binding
- protein binding
- identical protein binding
- ATPase
- heme ABC exporter, ATP-binding protein CcmA
- ABC transporter transmembrane region 2
- long-chain fatty acid transporter
- cobalt transport protein ATP-binding subunit
- transmembrane domain
- protein homodimerization
- nickel import ATP-binding protein NikE
- nucleotide binding fold domain
- ABC transporter
- acyl-CoA hydrolase
- P-loop containing Nucleoside Triphosphate Hydrolases
- transporter
- hydrophobic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- colon epithelial cancer
- congenital bile acid synthesis defect type 5
- Zellweger syndrome
- colon carcinoma
- early onset hypertension
- experimentally-induced diabetes
- multiple sclerosis
regulates
- lipid
- adenosine triphosphate
- ADP
- fatty acid
- long chain fatty acid
- phytanic acid
- lignoceric acid
- palmitic acid
- very long chain fatty acid
- ABCD3
role in cell
- expression in
- tubulation
- metabolism in
- organization
- fragmentation
- biogenesis
- fragmentation in
- biogenesis in
- beta-oxidation in
- tubulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- peroxisome-associated lamellae
- peroxisomal matrix
- intracellular membrane-bounded organelle
- cellular membrane
- Mitochondria
- cytosol
- peroxisome membrane
- peroxisomes
- peroxisomal fraction
- peroxisome-enriched fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Abcd3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fatty acid beta-oxidation
- peroxisome organization
- very long-chain fatty acid catabolic process
- response to xenobiotic stimulus
- response to organic cyclic compound
- bile acid biosynthetic process
- very long-chain fatty acid metabolic process
- fatty acid biosynthetic process
- peroxisomal long-chain fatty acid import
- bile acid and bile salt transport
Cellular Component
Where in the cell the gene product is active
- peroxisomal membrane
- peroxisome
- intracellular membrane-bounded organelle
- membrane
- mitochondrion
- cytosol
- peroxisomal matrix
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- ATPase activity, coupled to transmembrane movement of substances
- protein binding
- protein homodimerization activity
- acyl-CoA hydrolase activity
- long-chain fatty acid transporter activity