Dnajb11 Gene Summary [Rat]
Predicted to enable misfolded protein binding activity; signaling receptor binding activity; and unfolded protein binding activity. Predicted to be involved in positive regulation of ATP-dependent activity and protein maturation. Predicted to act upstream of or within mRNA modification and negative regulation of neurogenesis. Part of endoplasmic reticulum chaperone complex. Human ortholog(s) of this gene implicated in polycystic kidney disease 6. Orthologous to human DNAJB11 (DnaJ heat shock protein family (Hsp40) member B11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dnajb11 |
| Official Name | DnaJ heat shock protein family (Hsp40) member B11 [Source:RGD Symbol;Acc:1307373] |
| Ensembl ID | ENSRNOG00000001803 |
| Bio databases IDs | |
| Aliases | DnaJ heat shock protein family (Hsp40) member B11 |
| Synonyms | 1810031F23Rik, ABBP-2, DJ9, DJB11, DnaJ heat shock protein family (Hsp40) member B11, EDJ, ERdj3, ERj3, ERj3p, LRRGT00084, PKD6, PRO1080, UNQ537 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dnajb11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DnaJ domain
- chaperone protein DnaJ
- DnaJ
- DnaJ molecular chaperone homology domain
- Ubl1_cv_Nsp3_N-like
- DnaJ C terminal domain
- glycine/phenylalanine rich domain
- protein binding
- receptor binding
- hydrophobic domain
Pathways
Biological processes and signaling networks where the Dnajb11 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- polycystic kidney disease 6 with or without polycystic liver disease
- tinnitus
- preeclampsia
- autosomal dominant polycystic kidney disease
- hereditary disorder
- polycystic kidney disease
- polycystic kidney disease type 6 without polycystic liver disease
- fibrosis
- ciliopathy
role in cell
- expression in
- differentiation
- upregulation in
- downregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- Nucleus
- Endoplasmic Reticulum
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dnajb11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of ATPase activity
- negative regulation of neurogenesis
- protein maturation
- protein folding
- mRNA modification
Cellular Component
Where in the cell the gene product is active
- nucleus
- endoplasmic reticulum lumen
- extracellular space
- membrane
- endoplasmic reticulum
- endoplasmic reticulum chaperone complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- unfolded protein binding
- receptor binding
- misfolded protein binding