Cga Gene Summary [Rat]
The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Details
| Type | Protein Coding |
| Official Symbol | Cga |
| Official Name | glycoprotein hormones, alpha polypeptide [Source:RGD Symbol;Acc:620436] |
| Ensembl ID | ENSRNOG00000009269 |
| Bio databases IDs | |
| Aliases | glycoprotein hormones, alpha polypeptide |
| Synonyms | aGSU, Alpha, alpha GONADOTROPIN, alpha-GSU, alphaSU, CG-ALPHA, CG-α, Common alpha, Common α, FSHA, Fsh Alpha, Fsh α, Glycoprotein hormone alpha, Glycoprotein hormone alpha subunit, glycoprotein hormones, alpha polypeptide, glycoprotein hormones, alpha subunit, glycoprotein hormones, α polypeptide, glycoprotein hormones, α subunit, Glycoprotein hormone α, Glycoprotein hormone α chain, Glycoprotein hormone α subunit, Gonadotropin, GONADOTROPIN alpha, Gonadotropin alpha subunit, GONADOTROPIN α, Gonadotropin α subunit, GPA1, GPHa, GPHA1, GPHalpha, HCG, Hcg alpha, Hcg α, LHA, Lh Alpha, LH and FSH COMMON alpha subunit, LH and FSH COMMON α subunit, Lh α, Pituitary Glycoprotein Hormone alpha subunit, Pituitary Glycoprotein Hormone α subunit, TSHA, Tsh Alpha, Tsh α, α, α GONADOTROPIN, α-GSU |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cga often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- follicle-stimulating hormone
- N-linked glycosylation site
- Glycoprotein hormone
- hormone
- protein binding
- glycosylation site
Pathways
Biological processes and signaling networks where the Cga gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- gastric cancer
- growth failure
- preeclampsia
- hyperplasia
- androgenic alopecia
- osteoporosis
- hypoplasia
- bleeding
- pituitary gland adenoma
role in cell
- activation in
- migration
- number
- apoptosis
- proliferation
- growth
- quantity
- hypertrophy
- maturation
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- Cytoplasm
- Nucleus
- Plasma Membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cga gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- organ growth
- G-protein coupled receptor signaling pathway
- luteinizing hormone secretion
- thyroid hormone generation
- positive regulation of cell proliferation
- follicle-stimulating hormone secretion
- negative regulation of organ growth
- positive regulation of transcription from RNA polymerase II promoter
- follicle-stimulating hormone signaling pathway
- hormone-mediated signaling pathway
- thyroid gland development
- regulation of receptor activity
- positive regulation of steroid biosynthetic process
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- follicle-stimulating hormone complex
- extracellular region
- Golgi lumen
Molecular Function
What the gene product does at the molecular level
- protein binding
- follicle-stimulating hormone activity
- hormone activity