Alk Gene Summary [Rat]
Predicted to enable several functions, including heparin binding activity; identical protein binding activity; and receptor signaling protein tyrosine kinase activator activity. Involved in nervous system development. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human ALK (ALK receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Alk |
| Official Name | ALK receptor tyrosine kinase [Source:RGD Symbol;Acc:628622] |
| Ensembl ID | ENSRNOG00000008683 |
| Bio databases IDs | |
| Aliases | ALK receptor tyrosine kinase |
| Synonyms | ALK1, ALK receptor, ALK receptor tyrosine kinase, anaplastic lymphoma kinase, B120IND1, CD246, LOC108351182, NBLST3, Tcrz |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Alk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Protein kinase (unclassified specificity)
- catalytic domain
- ATP-binding domain
- Protein tyrosine and serine/threonine kinase
- protein binding
- protein-tyrosine kinase
- Protein kinase domain
- identical protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
- Protein Kinases, catalytic domain
- transmembrane receptor protein tyrosine kinase
- cytoplasmic domain
- LDLa
- tyrosine kinase domain
- intracellular domain
- receptor signaling protein tyrosine kinase activator
- heparin binding
- Tyrosine kinase, catalytic domain
- MAM domain, meprin/A5/mu
- Coagulation Factor Xa inhibitory site
Pathways
Biological processes and signaling networks where the Alk gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- de novo acute myeloid leukemia
- precursor B-cell acute lymphoblastic leukemia
- neoplasia
- advanced lung squamous cell carcinoma
- advanced colon cancer
- advanced large cell lung carcinoma
- acute myeloid leukemia
- ALK rearrangement positive non-small cell lung cancer
- non-small cell lung cancer
- stage II non-small cell lung cancer
regulated by
- heavy metal
- beta-estradiol
- tretinoin
- DNMT1
- MMP-9 inhibitor I
- methylnitrosourea
- crizotinib
- MYC/MYCN:ALK gene
- EML4-ALK
- iruplinalkib
role in cell
- phosphorylation in
- activation in
- expression in
- migration
- quantity
- differentiation
- proliferation
- cell viability
- response
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- Nucleus
- Golgi Apparatus
- nucleoli
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Alk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organismal development
- signal transduction
- protein autophosphorylation
- peptidyl-tyrosine autophosphorylation
- transmembrane receptor protein tyrosine kinase signaling pathway
- regulation of apoptotic process
- hippocampus development
- regulation of neuron differentiation
- neuron development
- positive regulation of NF-kappaB transcription factor activity
- regulation of dopamine receptor signaling pathway
- positive regulation of dendrite development
- regulation of cell proliferation
- energy homeostasis
- positive regulation of kinase activity
- phosphorylation
- adult behavior
- negative regulation of lipid catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- receptor complex
- macromolecular complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein tyrosine kinase activity
- identical protein binding
- protein binding
- transmembrane receptor protein tyrosine kinase activity
- heparin binding
- receptor signaling protein tyrosine kinase activator activity