Itpr1 Gene Summary [Rat]
This gene belongs to the Insp3 receptor family. It encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
Details
| Type | Protein Coding |
| Official Symbol | Itpr1 |
| Official Name | inositol 1,4,5-trisphosphate receptor, type 1 [Source:RGD Symbol;Acc:2933] |
| Ensembl ID | ENSRNOG00000007104 |
| Bio databases IDs | |
| Aliases | inositol 1,4,5-trisphosphate receptor, type 1 |
| Synonyms | ACV, CLA4, D6Pas2, DKFZp313N1434, Gm10429, I145TR, inositol 1,4,5-trisphosphate receptor 1, inositol 1,4,5-trisphosphate receptor type 1, inositol 1,4,5-trisphosphate receptor, type 1, InsP3R, INSP3R1, IP3R, IP3R 1, Ip3 receptor, Ip3 Receptor Type 1, opt, P400, Pcd6, Pcp-1, PPP1R94, SCA15, SCA16, SCA29, Type I IP3 receptor, wblo |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Itpr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- inositol 1,4,5-triphosphate-sensitive calcium-release channel
- regulatory domain
- ATP binding
- RIH domain
- MIR domain
- RXGX motif
- pore domain
- identical protein binding
- ion channel
- BH3-like domain
- RyR and IP3R Homology associated
- ligand-binding domain
- Inositol 1,4,5-trisphosphate/ryanodine receptor
- ion channel binding
- tail domain
- leucine/Isoleucine zipper domain
- IP3-binding core domain
- calcium channel inhibitor
- Ion transport protein
- calcium ion transporter
- Akt phosphorylation site
- protein phosphatase binding
- calmodulin binding domain
- IP3 binding domain
- protein domain specific binding
- protein binding
- beta-trefoil_MIR
- inositol phosphate binding domain
- calcium-release channel
- phosphatidylinositol binding
- conserved domain
- inositol 1,4,5-triphosphate receptor binding domain
- IP3-binding suppressor domain
- binding protein
- transmembrane domain
- protein homodimerization
- suppressor domain
- cytosolic tail domain
- modulatory domain
Pathways
Biological processes and signaling networks where the Itpr1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Apelin Cardiomyocyte Signaling Pathway
- Calcium Signaling
- CCR3 Signaling in Eosinophils
- Cellular Effects of Sildenafil (Viagra)
- Cholecystokinin/Gastrin-mediated Signaling
- Corticotropin Releasing Hormone Signaling
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- EGF Signaling
- eNOS Signaling
- FGF Signaling
- fMLP Signaling in Neutrophils
- G Beta Gamma Signaling
- GDNF Family Ligand-Receptor Interactions
- Glioblastoma Multiforme Signaling
- Gustation Pathway
- Netrin Signaling
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- nNOS Signaling in Skeletal Muscle Cells
- Renin-Angiotensin Signaling
- Synaptic Long Term Potentiation
- Thrombin Signaling
- Type II Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- non-insulin-dependent diabetes mellitus
- neoplasia
- spinocerebellar ataxia 15
- aniridia, cerebellar ataxia, and mental retardation
- spinocerebellar ataxia type 29
- hereditary disorder
- hepatic steatosis
- Huntington disease
- anterior segment dysgenesis
role in cell
- proliferation
- apoptosis
- expression in
- cell death
- binding in
- formation
- growth
- activation in
- extension
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- endoplasmic reticulum fraction
- detergent-soluble membrane fractions
- membrane fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- intracellular membrane-bounded organelle
- subsynaptic nuclei
- presynaptic regions
- cell surface
- apical compartment
- perinuclear region
- postsynaptic region
- intracellular membranes
- cellular membrane
- focal adhesions
- Nucleus
- Plasma Membrane
- sarcoplasmic reticulum
- Golgi Apparatus
- Endoplasmic Reticulum
- secretory granule membrane
- cytosol
- endoplasmic reticulum membrane
- microsome
- synaptic membrane
- Golgi membrane
- mitochondrial membrane
- inner nuclear membrane
- nucleoli
- nuclear envelope
- alpha granule membranes
- neuromuscular junctions
- synaptosomes
- synapse
- smooth endoplasmatic reticulum
- microsomal membrane
- perikaryon
- dendrites
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Itpr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- negative regulation of calcium-mediated signaling
- cell morphogenesis
- post-embryonic development
- cytosolic calcium ion homeostasis
- epithelial fluid transport
- single fertilization
- phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
- protein homotetramerization
- voluntary musculoskeletal movement
- response to hypoxia
- regulation of autophagy
- calcium ion transport
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
- positive regulation of insulin secretion
- release of sequestered calcium ion into cytosol
- endoplasmic reticulum calcium ion homeostasis
- calcium-mediated signaling
Cellular Component
Where in the cell the gene product is active
- platelet dense tubular network
- postsynaptic density
- sarcoplasmic reticulum
- platelet dense tubular network membrane
- endoplasmic reticulum
- nucleolus
- plasma membrane
- endoplasmic reticulum membrane
- secretory granule membrane
- nuclear inner membrane
- perinuclear region of cytoplasm
- transport vesicle membrane
- calcineurin complex
- membrane
- platelet dense granule membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- calcium-release channel activity
- protein domain specific binding
- protein binding
- calcium ion binding
- phosphatidylinositol binding
- calcium ion transmembrane transporter activity
- inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
- calcium channel inhibitor activity
- inositol 1,4,5 trisphosphate binding