Paxbp1 Gene Summary [Rat]
Predicted to enable histone methyltransferase binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of myoblast proliferation and regulation of skeletal muscle satellite cell proliferation. Predicted to be active in nucleus. Orthologous to human PAXBP1 (PAX3 and PAX7 binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Paxbp1 |
| Official Name | PAX3 and PAX7 binding protein 1 [Source:RGD Symbol;Acc:1584739] |
| Ensembl ID | ENSRNOG00000002036 |
| Bio databases IDs | |
| Aliases | PAX3 and PAX7 binding protein 1 |
| Synonyms | 1810007M14Rik, AI021902, BM020, C21orf66, FSAP105, GCFC, GCFC1, GC-rich sequence DNA-binding factor candidate, LOC683880, Pax3/7bp, PAX3 and PAX7 binding protein 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Paxbp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme binding
- transcription factor binding
- GC-rich sequence DNA-binding factor-like protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- spliceosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Paxbp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle organ development
- positive regulation of myoblast proliferation
- transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- regulation of satellite cell proliferation
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
Molecular Function
What the gene product does at the molecular level
- DNA binding