Set Gene Summary [Rat]
Predicted to enable ATP binding activity; diacylglycerol-dependent serine/threonine kinase activity; and small GTPase binding activity. Predicted to be involved in epithelial cell migration. Orthologous to human PKN3 (protein kinase N3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Set |
| Official Name | SET nuclear proto-oncogene [Source:RGD Symbol;Acc:1307467] |
| Ensembl ID | ENSRNOG00000025892 |
| Bio databases IDs | |
| Aliases | SET nuclear proto-oncogene |
| Synonyms | LRRGT00147, PKNBETA, protein kinase N3, UTDP4-1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Set often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein kinase (unclassified specificity)
- protein kinase
- Protein kinase C terminal domain
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- Extension to Ser/Thr-type protein kinases
- Tyrosine kinase, catalytic domain
- Hr1 repeat
- C2 domain
- HR1
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Golgi Apparatus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Set gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- peptidyl-serine phosphorylation
- protein phosphorylation
- epithelial cell migration
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytosol
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- small GTPase binding
- protein kinase activity
- protein serine/threonine kinase activity
- protein kinase C activity