Map3k8 Gene Summary [Rat]
Enables MAP kinase kinase kinase activity. Involved in cardiac ventricle development and gap junction-mediated intercellular transport. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in clear cell renal cell carcinoma; lung cancer; and stomach cancer. Orthologous to human MAP3K8 (mitogen-activated protein kinase kinase kinase 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Map3k8 |
| Official Name | mitogen-activated protein kinase kinase kinase 8 [Source:RGD Symbol;Acc:620969] |
| Ensembl ID | ENSRNOG00000016378 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase kinase kinase 8 |
| Synonyms | AURA2, c-COT, COT, Cot/Tpl2, D17TPL2, EST, ESTF, MEKK8, mitogen-activated protein kinase kinase kinase 8, PROTO-COT, TPL2, tumour progression locus 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Map3k8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- ATP-binding domain
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- MAP kinase kinase kinase
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- alcohol group acceptor phosphotransferase
- Tyrosine kinase, catalytic domain
- STY-rich domain
Pathways
Biological processes and signaling networks where the Map3k8 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- B Cell Receptor Signaling
- Cardiac Hypertrophy Signaling
- CD27 Signaling in Lymphocytes
- ERK5 Signaling
- G-Protein Coupled Receptor Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- GNRH Signaling
- HGF Signaling
- IL-12 Signaling and Production in Macrophages
- Natural Killer Cell Signaling
- NF-κB Signaling
- NGF Signaling
- PKCθ Signaling in T Lymphocytes
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- RANK Signaling in Osteoclasts
- Sertoli Cell-Sertoli Cell Junction Signaling
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- edema
- ulcerative colitis
- inflammatory bowel disease
- neoplasia
- cancer
- hepatitis
- hepatic necrosis
- experimental autoimmune encephalomyelitis
- hypernociception
- bleomycin-induced pulmonary fibrosis
role in cell
- expression in
- phosphorylation in
- proliferation
- activation in
- recruitment
- accumulation
- production in
- activation
- quantity
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Map3k8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- T cell costimulation
- protein phosphorylation
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- protein binding
- MAP kinase kinase kinase activity
- protein serine/threonine kinase activity