Snrnp70 Gene Summary [Rat]
Enables U1 snRNP binding activity. Involved in cellular response to retinoic acid; cellular response to transforming growth factor beta stimulus; and cellular response to tumor necrosis factor. Part of U1 snRNP. Human ortholog(s) of this gene implicated in disease of mental health and systemic lupus erythematosus. Orthologous to human SNRNP70 (small nuclear ribonucleoprotein U1 subunit 70). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Snrnp70 |
| Official Name | small nuclear ribonucleoprotein U1 subunit 70 [Source:RGD Symbol;Acc:1307120] |
| Ensembl ID | ENSRNOG00000020763 |
| Bio databases IDs | |
| Aliases | small nuclear ribonucleoprotein U1 subunit 70 |
| Synonyms | 2700022N21Rik, 3200002N22Rik, RNPU1Z, Rnu1p70, Rnulp70, RPU1, small nuclear ribonucleoprotein 70 (U1), small nuclear ribonucleoprotein U1 subunit 70, Snp1, SNRP70, Srnp70, U1-70, U1-70K, U1AP, U1RNP, U1 SNRNP70, U1 SNRNP 70K |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Snrnp70 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- U1 snRNA binding
- arginine serine dipeptide repeat domain
- RNA recognition motif (RRM) superfamily
- low complexity domain
- RNA recognition motif
- U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
- ribonucleoprotein binding
- protein binding
- SR domain
- RNA binding
Pathways
Biological processes and signaling networks where the Snrnp70 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- hypertension
role in cell
- expression in
- splicing by
- accumulation in
- replication in
- alternative splicing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- spliceosomes
- nucleoplasm
- interchromatin granule clusters
- nuclear speckles
- nuclear granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Snrnp70 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of nuclear mRNA splicing, via spliceosome
- regulation of ATPase activity
- regulation of RNA splicing
- negative regulation of protein refolding
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- spliceosomal complex
- U2-type prespliceosome
- U1 snRNP
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- U1 snRNA binding
- mRNA binding