Spata18 Gene Summary [Rat]
Predicted to enable cardiolipin binding activity; identical protein binding activity; and molecular condensate scaffold activity. Predicted to be involved in mitochondrial protein catabolic process; mitophagy by internal vacuole formation; and positive regulation of cardiolipin metabolic process. Located in sperm flagellum. Orthologous to human SPATA18 (spermatogenesis associated 18). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spata18 |
| Official Name | spermatogenesis associated 18 [Source:RGD Symbol;Acc:735208] |
| Ensembl ID | ENSRNOG00000002120 |
| Bio databases IDs | |
| Aliases | spermatogenesis associated 18 |
| Synonyms | 1700067I02Rik, Mieap, spermatogenesis associated 18, SPETEX1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Spata18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mitochondria-eating protein
- phospholipid binding
- Autophagy protein 16 (ATG16)
- binding protein
- protein binding activity, bridging
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nonobstructive azoospermia
regulates
- adenosine triphosphate
- cardiolipin
- 70:4 cardiolipin
- 72:6 cardiolipin
- 72:5 cardiolipin
- 68:5 cardiolipin
- 68:4 cardiolipin
- 72:4 cardiolipin
- 70:6 cardiolipin
role in cell
- mitochondrial respiration in
- formation
- production in
- modification in
- modification
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- organelle
- Mitochondria
- cytosol
- mitochondrial matrix
- mitochondrial outer membrane
- nucleoplasm
- sperm tail
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Spata18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial protein catabolic process
- mitochondrion degradation by induced vacuole formation
- response to DNA damage stimulus
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- intracellular membrane-bounded organelle
- mitochondrion
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding