Cds1 Gene Summary [Rat]
Enables phosphatidate cytidylyltransferase activity. Predicted to be involved in glycerophospholipid biosynthetic process; lipid droplet formation; and positive regulation of fat cell differentiation. Located in endoplasmic reticulum membrane. Orthologous to human CDS1 (CDP-diacylglycerol synthase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cds1 |
| Official Name | CDP-diacylglycerol synthase 1 [Source:RGD Symbol;Acc:621185] |
| Ensembl ID | ENSRNOG00000002142 |
| Bio databases IDs | |
| Aliases | CDP-diacylglycerol synthase 1 |
| Synonyms | 4833409J18Rik, CDP-diacylglycerol synthase 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cds1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphatidate cytidylyltransferase
- catalytic domain
- SQ/TQ cluster domain
- enzyme
- protein binding
- Cytidylyltransferase family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- heart failure
- diabetic nephropathy
- experimentally-induced diabetes
- endometriosis
- Huntington disease
regulates
- 17:0 phosphatidic acid
- 14:0 phosphatidic acid
- phosphatidic acid
- phosphatidylinositol
- 16:0 phosphatidic acid
- CDP-diacylglycerol
- 17:1 phosphatidic acid
- 18:0 phosphatidic acid
- 27:6 phosphatidic acid
role in cell
- differentiation
- formation
- formation in
- G1 phase
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cds1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- CDP-choline pathway
- signal transduction
- positive regulation of fat cell differentiation
- CDP-diacylglycerol biosynthetic process
- phosphatidylinositol biosynthetic process
- phototransduction
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- phosphatidate cytidylyltransferase activity
- diacylglycerol cholinephosphotransferase activity