Slc9a1 Gene Summary [Rat]
Enables sodium:proton antiporter activity. Involved in several processes, including cellular response to cold; cellular response to electrical stimulus; and regulation of apoptotic process. Located in several cellular components, including T-tubule; basolateral plasma membrane; and intercalated disc. Used to study cataract; middle cerebral artery infarction; and proteinuria. Biomarker of hyperthyroidism; hypothyroidism; renovascular hypertension; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 19 and congestive heart failure. Orthologous to human SLC9A1 (solute carrier family 9 member A1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc9a1 |
| Official Name | solute carrier family 9 member A1 [Source:RGD Symbol;Acc:3718] |
| Ensembl ID | ENSRNOG00000007982 |
| Bio databases IDs | |
| Aliases | solute carrier family 9 member A1 |
| Synonyms | APNH, APNH1, Chloride-dependent Na+-H+ exchanger, Cl-NHE, LIKNS, Mir5122, NHE-1, PPP1R143, Slc9a1 variant Cl-NHE, Sodium/proton exchanger, solute carrier family 9 member A1, solute carrier family 9 (sodium/hydrogen exchanger), member 1, swe |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc9a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Regulatory region of Na+/H+ exchanger NHE binds to calmodulin
- phospholipid binding
- calcium-dependent protein binding
- RXXs motif
- Sodium/hydrogen exchanger family
- regulatory domain
- protein binding activity, bridging
- protein binding
- identical protein binding
- ion channel
- sodium:hydrogen antiporter
- ERM binding domain
- cytoplasmic domain
- protein phosphatase 2B binding
- phosphatidylinositol-4,5-bisphosphate binding
- transmembrane domain
- sodium/hydrogen exchanger 3
- cytosolic tail domain
- transporter
Pathways
Biological processes and signaling networks where the Slc9a1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- essential hypertension
- irritable bowel syndrome characterized by constipation
- cardiovascular disorder
- non-insulin-dependent diabetes mellitus
- congestive heart failure
- disorder of coronary artery
- Lichtenstein-Knorr syndrome
- abdominal aortic aneurysm
- alkalinization
regulated by
- amiloride
- D-glucose
- docosahexaenoic acid
- rosiglitazone
- potassium chloride
- insulin
- THRA
- PP1
- paclitaxel
- calcitriol
role in cell
- apoptosis
- production in
- number
- expression in
- activation in
- quantity
- cell death
- differentiation
- cell viability
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- raft fractions
- pinceau synapse
- Cytoplasm
- invadopodia
- cell surface
- intracellular space
- perinuclear region
- membrane surface
- cellular membrane
- Endoplasmic Reticulum
- intercellular junctions
- apical cell surfaces
- microsome
- apical membrane
- plasma membrane projections
- basolateral membrane
- nucleoplasm
- synaptic vesicles
- growth cone
- neurites
- intercalated disks
- sarcolemma
- transverse tubules
- membrane rafts
- brush border
- membrane tufts
- pseudopodia
- perikaryon
- axon terminals
- mossy fiber boutons
- lamellipodia
- parallel fiber
- mossy fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc9a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cardiac muscle cell membrane potential
- regulation of stress fiber assembly
- cellular sodium ion homeostasis
- positive regulation of transcription from RNA polymerase II promoter
- regulation of pH
- cellular response to insulin stimulus
- positive regulation of cell growth
- ion transport
- stem cell differentiation
- cellular response to epinephrine stimulus
- positive regulation of calcineurin-NFAT signaling cascade
- cellular response to electrical stimulus
- positive regulation of cardiac muscle hypertrophy
- cellular response to hypoxia
- cellular response to antibiotic
- response to muscle stretch
- cell migration
- cardiac muscle cell differentiation
- cardiac muscle cell contraction
- positive regulation of mitochondrial membrane permeability
- potassium ion transmembrane transport
- cellular response to mechanical stimulus
- regulation of focal adhesion assembly
- regulation of intracellular pH
- positive regulation of action potential
- negative regulation of apoptotic process
- positive regulation of apoptotic process
- cellular response to acidity
- maintenance of cell polarity
- response to acidity
- regulation of the force of heart contraction by cardiac conduction
- regulation of cardiac muscle contraction by calcium ion signaling
- cellular response to cold
- cellular response to organic cyclic compound
- protein oligomerization
Cellular Component
Where in the cell the gene product is active
- plasma membrane
- cell surface
- nucleoplasm
- T-tubule
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
- membrane raft
- mitochondrion
- membrane
- intercalated disc
- basolateral plasma membrane
- apical plasma membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- potassium:hydrogen antiporter activity
- sodium:hydrogen antiporter activity
- calcium-dependent protein binding
- phospholipid binding
- phosphatidylinositol-4,5-bisphosphate binding
- calmodulin binding
- protein binding
- protein binding, bridging
- sodium:hydrogen antiporter activity involved in regulation of cardiac muscle cell membrane potential
- protein phosphatase 2B binding
- binding, bridging