Maged2 Gene Summary [Rat]
Predicted to be involved in female pregnancy; negative regulation of transcription by RNA polymerase II; and renal sodium ion absorption. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Bartter disease type 5. Orthologous to human MAGED2 (MAGE family member D2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Maged2 |
| Official Name | MAGE family member D2 [Source:RGD Symbol;Acc:70899] |
| Ensembl ID | ENSRNOG00000002449 |
| Bio databases IDs | |
| Aliases | MAGE family member D2 |
| Synonyms | 11B6, 4833439A22RIK, BARTS5, BCG-1, HCA10, MAGE family member D2, ORF1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Maged2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MAGE homology domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast carcinoma
- organismal death
- glioblastoma
- glioblastoma cancer
- transient antenatal Bartter syndrome type 5
- amyotrophic lateral sclerosis
- low-grade glioma
- glioma formation
- diffuse astrocytoma
role in cell
- apoptosis
- phosphorylation in
- migration
- expression in
- proliferation
- growth
- number
- invasion by
- autophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- Extracellular Space
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
- alpha granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Maged2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- renal sodium ion absorption
- female pregnancy
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- nucleus
- membrane
- cytosol
- extracellular region
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding