Chrm3 Gene Summary [Rat]
Enables several functions, including G protein-coupled acetylcholine receptor activity; G protein-coupled acetylcholine receptor binding activity; and acetylcholine binding activity. Involved in G protein-coupled acetylcholine receptor signaling pathway; negative regulation of heart rate by acetylcholine; and positive regulation of vascular associated smooth muscle contraction. Located in several cellular components, including asymmetric synapse; axon terminus; and dendrite. Is active in glutamatergic synapse; postsynaptic density membrane; and presynaptic membrane. Human ortholog(s) of this gene implicated in bladder disease; chronic obstructive pulmonary disease; prune belly syndrome; and pulmonary fibrosis. Orthologous to human CHRM3 (cholinergic receptor muscarinic 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chrm3 |
| Official Name | cholinergic receptor, muscarinic 3 [Source:RGD Symbol;Acc:2343] |
| Ensembl ID | ENSRNOG00000049410 |
| Bio databases IDs | |
| Aliases | cholinergic receptor, muscarinic 3 |
| Synonyms | cholinergic receptor muscarinic 3, cholinergic receptor, muscarinic 3, cholinergic receptor, muscarinic 3, cardiac, EGBRS, HM3, LOC105373226, LOC107983951, M3, m3AChR, M3 mAChR, M3 MUSCARINIC receptor, M3R, M3 receptor, PBS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Chrm3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- G-protein coupled acetylcholine receptor
- intracellular loop
- signaling receptor activity
- binding protein
- cytoplasmic loop
- G-protein-coupled receptor binding
- transmembrane domain
- protein binding
- acetylcholine binding
Pathways
Biological processes and signaling networks where the Chrm3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- urinary tract infection
- lung cancer
- prostate cancer
- breast cancer
- epithelial cancer
- epithelial neoplasia
- cancer
- adenoma formation
- benign neoplasia
- iritis
role in cell
- apoptosis
- formation
- activation in
- cell death
- proliferation
- synthesis in
- growth
- phosphorylation in
- chemotaxis
- fragmentation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- membrane fraction
- synaptosomal membrane fractions
- glutaminergic synapse
- cellular membrane
- presynaptic membrane
- synaptic membrane
- basolateral membrane
- basal membrane
- synapse
- tight junctions
- dendrites
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Chrm3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synaptic transmission, cholinergic
- protein modification process
- adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
- G-protein coupled receptor signaling pathway
- signal transduction
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- nervous system development
- synaptic transmission
- G-protein coupled acetylcholine receptor signaling pathway
- positive regulation of smooth muscle contraction
- regulation of smooth muscle contraction
- phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
- saliva secretion
- smooth muscle contraction
- positive regulation of insulin secretion
- calcium-mediated signaling
- regulation of ion transmembrane transporter activity
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- dendrite
- basal plasma membrane
- postsynaptic membrane
- synapse
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol phospholipase C activity
- protein binding
- signaling receptor activity
- acetylcholine binding
- G-protein coupled acetylcholine receptor activity
- serotonin receptor activity