Atg5 Gene Summary [Rat]
Predicted to contribute to Atg8-family ligase activity. Involved in several processes, including chaperone-mediated autophagy; positive regulation of stress granule assembly; and response to iron(II) ion. Located in axon. Part of protein-containing complex. Is active in glutamatergic synapse. Biomarker of ischemia and metabolic dysfunction-associated steatohepatitis. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 25. Orthologous to human ATG5 (autophagy related 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atg5 |
| Official Name | autophagy related 5 [Source:RGD Symbol;Acc:1359580] |
| Ensembl ID | ENSRNOG00000000322 |
| Bio databases IDs | |
| Aliases | autophagy related 5 |
| Synonyms | 2010107M05Rik, 3110067M24Rik, APG5, APG5L, APG5-LIKE, APOPTOSIS SPECIFIC, ASP, Atg5l, autophagy related 5, hAPG5, PADDY, POT1, SCAR25 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Atg5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Autophagy protein Apg5
- APG8 conjugating enzyme
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Atg5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- neoplasia
- osteoarthritis
- cancer
- natural killer cell neoplasm
- natural killer cell neoplasia
- organismal death
- systemic lupus erythematosus
- experimentally induced pancreatitis
- insomnia
role in cell
- cell death
- number
- proliferation
- apoptosis
- expression in
- invasion by
- migration
- signaling in
- accumulation
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- endoplasmic reticulum mitochondria contact site
- autophagosomal membrane
- cellular membrane
- Plasma Membrane
- Mitochondria
- axonemes
- granules
- cytosol
- synapse
- autophagic vacuoles
- axons
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Atg5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart contraction
- response to iron(II) ion
- vasodilation
- response to xenobiotic stimulus
- chromatin organization
- negative regulation of innate immune response
- post-translational protein modification
- autophagic vacuole assembly
- piecemeal microautophagy of nucleus
- cardiac muscle cell apoptotic process
- otolith development
- autophagy
- antigen processing and presentation of endogenous antigen
- regulation of cytokine production involved in immune response
- establishment of localization in cell
- negative regulation of protein ubiquitination
- aggrephagy
- macroautophagy
- negative regulation of reactive oxygen species metabolic process
- negative regulation of type I interferon production
- response to fungus
- macromitophagy
- mitochondrion degradation
- cellular response to nitrogen starvation
- regulation of release of sequestered calcium ion into cytosol
- blood vessel remodeling
- mucus secretion
- ventricular cardiac muscle cell development
- cellular response to nitrosative stress
- negative regulation of cardiac muscle cell apoptotic process
- positive regulation of mucus secretion
- negative thymic T cell selection
- negative regulation of defense response to virus
- protein ubiquitination
- negative regulation of phagocytosis
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- pre-autophagosomal structure membrane
- membrane
- Atg12-Atg5-Atg16 complex
- phagocytic vesicle membrane
- ER-mitochondrion membrane contact site
- cytosol
- macromolecular complex
- autophagic vacuole
- axon
- axoneme
Molecular Function
What the gene product does at the molecular level
- protein binding
- Atg8 ligase activity