Prm2 Gene Summary [Rat]
Predicted to enable cadmium ion binding activity and zinc ion binding activity. Predicted to be involved in nucleus organization and spermatid development. Predicted to be located in male germ cell nucleus. Predicted to be part of nucleosome. Predicted to be active in nucleus. Orthologous to human PRM2 (protamine 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prm2 |
| Official Name | protamine 2 [Source:RGD Symbol;Acc:3409] |
| Ensembl ID | ENSRNOG00000002539 |
| Bio databases IDs | |
| Aliases | protamine 2 |
| Synonyms | CT94.2, PROTA2, protamine 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Prm2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc ion binding
- protein binding
- cadmium ion binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- teratozoospermia
- infertility condition
- nonobstructive azoospermia
role in cell
- organization
- development
- condensation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Prm2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatid development
- chromosome organization
- spermatogenesis
- chromosome condensation
- nucleus organization
- sequestering of metal ion
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleosome
- nucleoplasm
- male germ cell nucleus
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- protein binding
- cadmium ion binding